Herpesvirus entry mediator

TNFRSF14
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JMA, 2AW2, 4FHQ, 4RSU
Identifiers
Aliases	TNFRSF14, ATAR, CD270, HVEA, HVEM, LIGHTR, TR2, tumor necrosis factor receptor superfamily member 14, TNF receptor superfamily member 14
External IDs	OMIM: 602746; MGI: 2675303; HomoloGene: 2833; GeneCards: TNFRSF14; OMA:TNFRSF14 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	2,565,382 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	155,013,020 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; spleen; ; right uterine tube; ; duodenum; ; transverse colon; ; mucosa of transverse colon; ; right adrenal cortex; ; canal of the cervix; ; blood; ; gastric mucosa;
	Top expressed in
	granulocyte; ; thymus; ; yolk sac; ; embryo; ; muscle of thigh; ; duodenum; ; lip; ; spleen; ; jejunum; ; blood;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	virus receptor activity; protein binding; tumor necrosis factor-activated receptor activity; ubiquitin protein ligase binding; cytokine binding;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; external side of plasma membrane;
Biological process	regulation of apoptotic process; T cell costimulation; tumor necrosis factor-mediated signaling pathway; multicellular organism development; cell surface receptor signaling pathway; response to lipopolysaccharide; regulation of cell population proliferation; immune response; apoptotic signaling pathway; viral entry into host cell; inflammatory response; viral process; negative regulation of alpha-beta T cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; positive regulation of T cell migration;
	Sources:Amigo / QuickGO
Orthologs
	8764
	230979
	ENSG00000273936; ENSG00000157873
	ENSMUSG00000042333
	Q92956
	Q80WM9
	NM_001297605; NM_003820
	NM_178931
	NP_001284534; NP_003811
	NP_849262
	Wikidata
View/Edit Human	View/Edit Mouse

Herpesvirus entry mediator (HVEM), also known as tumor necrosis factor receptor superfamily member 14 (TNFRSF14), is a human cell surface receptor of the TNF-receptor superfamily^[5]^[6]^[7]^[8] encoded by the TNFRSF14 gene.^[7]

^ ^a ^b ^c ENSG00000157873 GRCh38: Ensembl release 89: ENSG00000273936, ENSG00000157873 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042333 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Montgomery RI, Warner MS, Lum BJ, Spear PG (November 1996). "Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family". Cell. 87 (3): 427–36. doi:10.1016/S0092-8674(00)81363-X. PMID 8898196. S2CID 14626053.
^ Kwon BS, Tan KB, Ni J, Oh KO, Lee ZH, Kim KK, Kim YJ, Wang S, Gentz R, Yu GL, Harrop J, Lyn SD, Silverman C, Porter TG, Truneh A, Young PR (May 1997). "A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation". The Journal of Biological Chemistry. 272 (22): 14272–6. doi:10.1074/jbc.272.22.14272. PMID 9162061.
^ ^a ^b "TNFRSF14 TNF receptor superfamily member 14 [ Homo sapiens (human) ]". Gene. National Library of Medicine, National Center for Biotechnology Information. 23 November 2023. Retrieved 5 January 2024.
^ Ware, Carl (2008). "Chapter 25: TNF-Related Cytokines in Immunity". In Paul, William (ed.). Fundamental Immunology (Book) (6th ed.). Philadelphia: Lippincott Williams & Wilkins. pp. 776–801. ISBN 978-0-7817-6519-0.

[refGRCh38Ensembl-1] ENSG00000157873 GRCh38: Ensembl release 89: ENSG00000273936, ENSG00000157873 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042333 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8898196-5] Montgomery RI, Warner MS, Lum BJ, Spear PG (November 1996). "Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family". Cell. 87 (3): 427–36. doi:10.1016/S0092-8674(00)81363-X. PMID 8898196. S2CID 14626053.

[pmid9162061-6] Kwon BS, Tan KB, Ni J, Oh KO, Lee ZH, Kim KK, Kim YJ, Wang S, Gentz R, Yu GL, Harrop J, Lyn SD, Silverman C, Porter TG, Truneh A, Young PR (May 1997). "A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation". The Journal of Biological Chemistry. 272 (22): 14272–6. doi:10.1074/jbc.272.22.14272. PMID 9162061.

[entrez-7] "TNFRSF14 TNF receptor superfamily member 14 [ Homo sapiens (human) ]". Gene. National Library of Medicine, National Center for Biotechnology Information. 23 November 2023. Retrieved 5 January 2024.

[Paul2508-8] Ware, Carl (2008). "Chapter 25: TNF-Related Cytokines in Immunity". In Paul, William (ed.). Fundamental Immunology (Book) (6th ed.). Philadelphia: Lippincott Williams & Wilkins. pp. 776–801. ISBN 978-0-7817-6519-0.

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