High-throughput screening

High-throughput screening (HTS) is a method for scientific discovery especially used in drug discovery and relevant to the fields of biology, materials science^[1] and chemistry.^[2]^[3] Using robotics, data processing/control software, liquid handling devices, and sensitive detectors, high-throughput screening allows a researcher to quickly conduct millions of chemical, genetic, or pharmacological tests. Through this process one can quickly recognize active compounds, antibodies, or genes that modulate a particular biomolecular pathway. The results of these experiments provide starting points for drug design and for understanding the noninteraction or role of a particular location.

^ Zhao, Yicheng; Heumueller, Thomas; Zhang, Jiyun; Luo, Junsheng; Kasian, Olga; Langner, Stefan; Kupfer, Christian; Liu, Bowen; Zhong, Yu; Elia, Jack; Osvet, Andres; Wu, Jianchang; Liu, Chao; Wan, Zhongquan; Jia, Chunyang; Li, Ning; Hauch, Jens; Brabec, Christoph J. (16 December 2021). "A bilayer conducting polymer structure for planar perovskite solar cells with over 1,400 hours operational stability at elevated temperatures". Nature Energy. 7 (2): 144–152. Bibcode:2022NatEn...7..144Z. doi:10.1038/s41560-021-00953-z. ISSN 2058-7546. S2CID 245285868.
^ Inglese J and Auld DS. (2009) Application of High Throughput Screening (HTS) Techniques: Applications in Chemical Biology in Wiley Encyclopedia of Chemical Biology (Wiley & Sons, Inc., Hoboken, NJ) Vol 2, pp 260–274 doi/10.1002/9780470048672.wecb223.
^ Macarron, R.; Banks, M.N.; Bojanic, D.; Burns, D.J.; Cirovic, D.A.; Garyantes, T.; Green, D.V.; Hertzberg, R.P.; Janzen, W.P.; Paslay, J.W.; Schopfer, U.; Sittampalam, G.S. (2011). "Impact of high-throughput screening in biomedical research". Nat Rev Drug Discov. 10 (3): 188–195. doi:10.1038/nrd3368. PMID 21358738. S2CID 205477370.

[1] Zhao, Yicheng; Heumueller, Thomas; Zhang, Jiyun; Luo, Junsheng; Kasian, Olga; Langner, Stefan; Kupfer, Christian; Liu, Bowen; Zhong, Yu; Elia, Jack; Osvet, Andres; Wu, Jianchang; Liu, Chao; Wan, Zhongquan; Jia, Chunyang; Li, Ning; Hauch, Jens; Brabec, Christoph J. (16 December 2021). "A bilayer conducting polymer structure for planar perovskite solar cells with over 1,400 hours operational stability at elevated temperatures". Nature Energy. 7 (2): 144–152. Bibcode:2022NatEn...7..144Z. doi:10.1038/s41560-021-00953-z. ISSN 2058-7546. S2CID 245285868.

[2] Inglese J and Auld DS. (2009) Application of High Throughput Screening (HTS) Techniques: Applications in Chemical Biology in Wiley Encyclopedia of Chemical Biology (Wiley & Sons, Inc., Hoboken, NJ) Vol 2, pp 260–274 doi/10.1002/9780470048672.wecb223.

[3] Macarron, R.; Banks, M.N.; Bojanic, D.; Burns, D.J.; Cirovic, D.A.; Garyantes, T.; Green, D.V.; Hertzberg, R.P.; Janzen, W.P.; Paslay, J.W.; Schopfer, U.; Sittampalam, G.S. (2011). "Impact of high-throughput screening in biomedical research". Nat Rev Drug Discov. 10 (3): 188–195. doi:10.1038/nrd3368. PMID 21358738. S2CID 205477370.

[1]

[2]

[3]