Histamine dihydrochloride

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Histamine dihydrochloride

Clinical data
Trade names	Ceplene
License data	EU EMA: by INN
Routes of administration	Subcutaneous injection, topical
ATC code	L03AX14 (WHO)
Legal status
Legal status	Approved for use in the EU (2008) and Israel (2011)
Identifiers
IUPAC name 2-(1H-imidazol-5-yl)ethanamine dihydrochloride
CAS Number	56-92-8
PubChem CID	11309913
ChemSpider	5613
UNII	3POA0Q644U
CompTox Dashboard (EPA)	DTXSID1058767
ECHA InfoCard	100.000.272
Chemical and physical data
Formula	C5H11Cl2N3
Molar mass	184.06 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1=C(NC=N1)CCN.Cl.Cl
InChI InChI=1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H Key:PPZMYIBUHIPZOS-UHFFFAOYSA-N

Histamine dihydrochloride (INN, trade name Ceplene) is a salt of histamine that is used as a drug for the prevention of relapse in patients diagnosed with acute myeloid leukemia (AML).

It is also an FDA-approved^[1] active ingredient for topical analgesic use for the temporary relief of minor aches and pains of muscles and joints associated with arthritis, simple backache, bruises, sprains, and strains and is available in over-the-counter (OTC) products such as Australian Dream and Golden Creme.^{[2] [3]}