Histone H4

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Structures	Swiss-model
Domains	InterPro

H4 histone, family 3
H4 histone, family 3
Identifiers
Symbol	H4F3
NCBI gene	3023
HGNC	4780
UniProt	P62805
Other data
Locus	Chr. 3 q13.13
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Histone H4 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H4 is involved with the structure of the nucleosome of the 'beads on a string' organization. Histone proteins are highly post-translationally modified. Covalently bonded modifications include acetylation and methylation of the N-terminal tails. These modifications may alter expression of genes located on DNA associated with its parent histone octamer.^[1]^[2] Histone H4 is an important protein in the structure and function of chromatin, where its sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes.

^ Bhasin M, Reinherz EL, Reche PA (2006). "Recognition and classification of histones using support vector machine" (PDF). Journal of Computational Biology. 13 (1): 102–112. doi:10.1089/cmb.2006.13.102. PMID 16472024.
^ Hartl DL, Freifelder D, Snyder LA (1988). Basic Genetics. Boston: Jones and Bartlett Publishers. ISBN 978-0-86720-090-4.

[Bhasin_2006-1] Bhasin M, Reinherz EL, Reche PA (2006). "Recognition and classification of histones using support vector machine" (PDF). Journal of Computational Biology. 13 (1): 102–112. doi:10.1089/cmb.2006.13.102. PMID 16472024.

[HartlFreilfelder&Snyder-2] Hartl DL, Freifelder D, Snyder LA (1988). Basic Genetics. Boston: Jones and Bartlett Publishers. ISBN 978-0-86720-090-4.

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