ICAM-1

ICAM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1D3E, 1D3I, 1D3L, 1IAM, 1IC1, 1MQ8, 1P53, 1Z7Z, 2OZ4, 3TCX
Identifiers
Aliases	ICAM1, BB2, CD54, P3.58, intercellular adhesion molecule 1
External IDs	OMIM: 147840; MGI: 96392; HomoloGene: 168; GeneCards: ICAM1; OMA:ICAM1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 10,271,093 bp[1] End 10,286,615 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A3|9 7.69 cM Start 20,927,281 bp[2] End 20,940,113 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vena cava upper lobe of left lung cartilage tissue right lung beta cell gallbladder lower lobe of lung spleen monocyte lymph node Top expressed in right lung lobe left lung left lung lobe mesenteric lymph nodes decidua spleen ankle joint gastrula thymus aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function virus receptor activity protein-containing complex binding integrin binding protein binding transmembrane signaling receptor activity signaling receptor activity Cellular component integral component of membrane membrane focal adhesion plasma membrane integral component of plasma membrane cell surface immunological synapse membrane raft extracellular exosome external side of plasma membrane extracellular space extracellular matrix collagen-containing extracellular matrix Biological process leukocyte cell-cell adhesion response to ionizing radiation establishment of endothelial barrier negative regulation of endothelial cell apoptotic process cellular response to organic substance heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules response to amino acid response to hypoxia positive regulation of actin filament polymerization response to organic cyclic compound T cell antigen processing and presentation establishment of Sertoli cell barrier response to sulfur dioxide response to copper ion interferon-gamma-mediated signaling pathway positive regulation of nitric oxide biosynthetic process response to amphetamine cellular response to tumor necrosis factor regulation of leukocyte mediated cytotoxicity T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell extracellular matrix organization acute inflammatory response to antigenic stimulus hearing cellular response to alkaloid response to gonadotropin positive regulation of cellular extravasation positive regulation of GTPase activity response to lipopolysaccharide regulation of cell adhesion cell adhesion cell adhesion mediated by integrin positive regulation of NF-kappaB transcription factor activity negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of vasoconstriction cellular response to interleukin-1 cellular response to nutrient levels negative regulation of calcium ion transport regulation of cell shape membrane to membrane docking positive regulation of peptidyl-tyrosine phosphorylation ovarian follicle development regulation of immune response positive regulation of ERK1 and ERK2 cascade regulation of ruffle assembly viral entry into host cell response to ethanol viral process cellular response to lipopolysaccharide cellular response to hypoxia leukocyte migration cellular response to glucose stimulus response to insulin cellular response to interferon-gamma cellular response to interleukin-6 cellular response to dexamethasone stimulus establishment of endothelial intestinal barrier positive regulation of leukocyte adhesion to vascular endothelial cell cellular response to leukemia inhibitory factor cell-cell adhesion cytokine-mediated signaling pathway T cell extravasation cellular response to amyloid-beta Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3383 15894 Ensembl ENSG00000090339 ENSMUSG00000037405 UniProt P05362 P13597 RefSeq (mRNA) NM_000201 NM_010493 RefSeq (protein) NP_000192 NP_034623 Location (UCSC) Chr 19: 10.27 – 10.29 Mb Chr 9: 20.93 – 20.94 Mb PubMed search [3] [4]
Wikidata
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ICAM-1 (Intercellular Adhesion Molecule 1) also known as CD54 (Cluster of Differentiation 54) is a protein that in humans is encoded by the ICAM1 gene.^[5][6] This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by rhinovirus as a receptor for entry into respiratory epithelium.^[7]