ICAM3

ICAM3
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1T0P
Identifiers
Aliases	ICAM3, CD50, CDW50, ICAM-R, intercellular adhesion molecule 3
External IDs	OMIM: 146631; HomoloGene: 88479; GeneCards: ICAM3; OMA:ICAM3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	10,339,661 bp
RNA expression pattern
	Top expressed in
	blood; ; granulocyte; ; monocyte; ; bone marrow cells; ; trabecular bone; ; periodontal fiber; ; spleen; ; lymph node; ; right lobe of liver; ; appendix;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	integrin binding; signaling receptor binding; protein binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; extracellular exosome; membrane;
Biological process	cell adhesion; extracellular matrix organization; stimulatory C-type lectin receptor signaling pathway; regulation of immune response; phagocytosis; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	3385
	n/a
	ENSG00000076662
	n/a
	P32942
	n/a
NM_002162; NM_001320605; NM_001320606; NM_001320608; NM_001395374;
	NM_001395375; NM_001395376
	n/a
	NP_001307534; NP_001307535; NP_001307537; NP_002153
	n/a
	Wikidata
View/Edit Human

Intercellular adhesion molecule 3 (ICAM3) also known as CD50 (Cluster of Differentiation 50), is a protein that in humans is encoded by the ICAM3 gene.^[3] The protein is constitutively expressed on the surface of leukocytes, which are also called white blood cells and are part of the immune system.^[4]^[5] ICAM3 mediates adhesion between cells by binding to specific integrin receptors.^[6] It plays an important role in the immune cell response through its facilitation of interactions between T cells and dendritic cells, which allows for T cell activation.^[7]^[8] ICAM3 also mediates the clearance of cells undergoing apoptosis by attracting and binding macrophages, a type of cell that breaks down infected or dying cells through a process known as phagocytosis, to apoptotic cells.^[6]^[9]^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000076662 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "ICAM3 intercellular adhesion molecule 3 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-03-10.
^ Xiao X, Mruk DD, Cheng CY (March 2013). "Intercellular adhesion molecules (ICAMs) and spermatogenesis". Human Reproduction Update. 19 (2): 167–186. doi:10.1093/humupd/dms049. PMC 3576004. PMID 23287428.
^ Pastwińska J, Żelechowska P, Walczak-Drzewiecka A, Brzezińska-Błaszczyk E, Dastych J (December 2020). "The Art of Mast Cell Adhesion". Cells. 9 (12): 2664. doi:10.3390/cells9122664. PMC 7764012. PMID 33322506.
^ ^a ^b Cockram TO, Dundee JM, Popescu AS, Brown GC (2021). "The Phagocytic Code Regulating Phagocytosis of Mammalian Cells". Frontiers in Immunology. 12: 629979. doi:10.3389/fimmu.2021.629979. ISSN 1664-3224. PMC 8220072. PMID 34177884.
^ Svajger U, Anderluh M, Jeras M, Obermajer N (October 2010). "C-type lectin DC-SIGN: an adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunity". Cellular Signalling. 22 (10): 1397–1405. doi:10.1016/j.cellsig.2010.03.018. PMC 7127357. PMID 20363321.
^ Gupta RK, Gupta GS (2012), Gupta GS (ed.), "Dendritic Cell Lectin Receptors (Dectin-2 Receptors Family)", Animal Lectins: Form, Function and Clinical Applications, Vienna: Springer, pp. 749–771, doi:10.1007/978-3-7091-1065-2_35, ISBN 978-3-7091-1065-2, retrieved 2022-03-11
^ Numata Y, Hirayama D, Wagatsuma K, Iida T, Nakase H (2018), Turksen K (ed.), "Apoptotic Cell Clearance in Gut Tissue: Role of Intestinal Regeneration", Autophagy in Health and Disease: Potential Therapeutic Approaches, Stem Cell Biology and Regenerative Medicine, Cham: Springer International Publishing, pp. 87–100, doi:10.1007/978-3-319-98146-8_6, ISBN 978-3-319-98146-8, retrieved 2022-03-09
^ Marek CJ, Erwig LP (2009), Dong Z, Yin XM (eds.), "Clearance of Apoptotic Cells – Mechanisms and Consequences", Essentials of Apoptosis: A Guide for Basic and Clinical Research, Totowa, NJ: Humana Press, pp. 261–282, doi:10.1007/978-1-60327-381-7_11, ISBN 978-1-60327-381-7, retrieved 2022-03-09

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000076662 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "ICAM3 intercellular adhesion molecule 3 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-03-10.

[:0-4] Xiao X, Mruk DD, Cheng CY (March 2013). "Intercellular adhesion molecules (ICAMs) and spermatogenesis". Human Reproduction Update. 19 (2): 167–186. doi:10.1093/humupd/dms049. PMC 3576004. PMID 23287428.

[:3-5] Pastwińska J, Żelechowska P, Walczak-Drzewiecka A, Brzezińska-Błaszczyk E, Dastych J (December 2020). "The Art of Mast Cell Adhesion". Cells. 9 (12): 2664. doi:10.3390/cells9122664. PMC 7764012. PMID 33322506.

[:4-6] Cockram TO, Dundee JM, Popescu AS, Brown GC (2021). "The Phagocytic Code Regulating Phagocytosis of Mammalian Cells". Frontiers in Immunology. 12: 629979. doi:10.3389/fimmu.2021.629979. ISSN 1664-3224. PMC 8220072. PMID 34177884.

[:23-7] Svajger U, Anderluh M, Jeras M, Obermajer N (October 2010). "C-type lectin DC-SIGN: an adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunity". Cellular Signalling. 22 (10): 1397–1405. doi:10.1016/j.cellsig.2010.03.018. PMC 7127357. PMID 20363321.

[:2-8] Gupta RK, Gupta GS (2012), Gupta GS (ed.), "Dendritic Cell Lectin Receptors (Dectin-2 Receptors Family)", Animal Lectins: Form, Function and Clinical Applications, Vienna: Springer, pp. 749–771, doi:10.1007/978-3-7091-1065-2_35, ISBN 978-3-7091-1065-2, retrieved 2022-03-11

[:7-9] Numata Y, Hirayama D, Wagatsuma K, Iida T, Nakase H (2018), Turksen K (ed.), "Apoptotic Cell Clearance in Gut Tissue: Role of Intestinal Regeneration", Autophagy in Health and Disease: Potential Therapeutic Approaches, Stem Cell Biology and Regenerative Medicine, Cham: Springer International Publishing, pp. 87–100, doi:10.1007/978-3-319-98146-8_6, ISBN 978-3-319-98146-8, retrieved 2022-03-09

[:8-10] Marek CJ, Erwig LP (2009), Dong Z, Yin XM (eds.), "Clearance of Apoptotic Cells – Mechanisms and Consequences", Essentials of Apoptosis: A Guide for Basic and Clinical Research, Totowa, NJ: Humana Press, pp. 261–282, doi:10.1007/978-1-60327-381-7_11, ISBN 978-1-60327-381-7, retrieved 2022-03-09

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