ID2

ID2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4AYA
Identifiers
Aliases	ID2, GIG8, ID2A, ID2H, bHLHb26, inhibitor of DNA binding 2, HLH protein, inhibitor of DNA binding 2
External IDs	OMIM: 600386; MGI: 96397; HomoloGene: 1632; GeneCards: ID2; OMA:ID2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	8,684,461 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	25,147,139 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; tibial arteries; ; saphenous vein; ; pericardium; ; right lobe of liver; ; granulocyte; ; trachea; ; lower lobe of lung; ; renal medulla; ; seminal vesicula;
	Top expressed in
	vas deferens; ; seminal vesicula; ; lobe of cerebellum; ; migratory enteric neural crest cell; ; cerebellar vermis; ; abdominal wall; ; dermis; ; left lung lobe; ; hand; ; parotid gland;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein dimerization activity; transmembrane transporter binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor activity; transcription factor binding;
Cellular component	nucleus; cytosol; cytoplasm; protein-containing complex;
Biological process	regulation of G1/S transition of mitotic cell cycle; rhythmic process; negative regulation of DNA-binding transcription factor activity; regulation of transcription, DNA-templated; positive regulation of transcription involved in G1/S transition of mitotic cell cycle; multicellular organism development; negative regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; metanephros development; natural killer cell differentiation; thigmotaxis; leukocyte differentiation; membranous septum morphogenesis; bundle of His development; heart development; circadian rhythm; adult locomotory behavior; entrainment of circadian clock; positive regulation of gene expression; negative regulation of gene expression; oligodendrocyte development; regulation of lipid metabolic process; olfactory bulb development; circadian regulation of gene expression; mammary gland epithelial cell proliferation; regulation of circadian rhythm; entrainment of circadian clock by photoperiod; enucleate erythrocyte differentiation; negative regulation of DNA binding; locomotor rhythm; negative regulation of B cell differentiation; positive regulation of fat cell differentiation; positive regulation of erythrocyte differentiation; positive regulation of macrophage differentiation; negative regulation of neuron differentiation; negative regulation of osteoblast differentiation; positive regulation of blood pressure; positive regulation of transcription, DNA-templated; cell development; cell maturation; Peyer's patch development; embryonic digestive tract morphogenesis; positive regulation of smooth muscle cell proliferation; neuron fate commitment; cell morphogenesis involved in neuron differentiation; positive regulation of astrocyte differentiation; negative regulation of oligodendrocyte differentiation; adipose tissue development; mammary gland alveolus development; epithelial cell differentiation involved in mammary gland alveolus development; endodermal digestive tract morphogenesis; cellular response to lithium ion; cellular senescence; negative regulation of neural precursor cell proliferation; neuron differentiation; regulation of cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	3398
	15902
	ENSG00000115738
	ENSMUSG00000020644
	Q02363
	P41136
	NM_002166
	NM_010496
	NP_002157
	NP_034626
	Wikidata
View/Edit Human	View/Edit Mouse

DNA-binding protein inhibitor ID-2 is a protein that in humans is encoded by the ID2 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115738 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020644 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hara E, Yamaguchi T, Nojima H, Ide T, Campisi J, Okayama H, et al. (January 1994). "Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts". The Journal of Biological Chemistry. 269 (3): 2139–2145. doi:10.1016/S0021-9258(17)42146-6. PMID 8294468.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115738 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020644 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8294468-5] Hara E, Yamaguchi T, Nojima H, Ide T, Campisi J, Okayama H, et al. (January 1994). "Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts". The Journal of Biological Chemistry. 269 (3): 2139–2145. doi:10.1016/S0021-9258(17)42146-6. PMID 8294468.

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