ID4

ID4
Identifiers
Aliases	ID4, IDB4, bHLHb27, inhibitor of DNA binding 4, HLH protein
External IDs	OMIM: 600581; MGI: 99414; HomoloGene: 1186; GeneCards: ID4; OMA:ID4 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.3 Start 19,837,370 bp[1] End 19,842,197 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 A5|13 24.71 cM Start 48,414,704 bp[2] End 48,419,502 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of hip skin of thigh ventricular zone germinal epithelium optic nerve hair follicle urethra thyroid gland seminal vesicula left lobe of thyroid gland Top expressed in olfactory tubercle Rostral migratory stream optic nerve medial dorsal nucleus lateral septal nucleus supraoptic nucleus nucleus accumbens aortic valve globus pallidus utricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein dimerization activity transcription corepressor activity protein binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity transcription factor binding Cellular component cytoplasm nucleus Biological process prostate gland stromal morphogenesis negative regulation of fat cell differentiation negative regulation of astrocyte differentiation regulation of transcription, DNA-templated negative regulation of neuron differentiation central nervous system myelination regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II transcription, DNA-templated seminal vesicle morphogenesis brain development positive regulation of gene expression positive regulation of osteoblast differentiation prostate gland epithelium morphogenesis negative regulation of oligodendrocyte differentiation circadian rhythm positive regulation of cell population proliferation prostate gland morphogenesis neuroblast proliferation cerebral cortex neuron differentiation cell population proliferation negative regulation of transcription, DNA-templated hippocampus development fat cell differentiation positive regulation of transcription by RNA polymerase II G1/S transition of mitotic cell cycle neuron differentiation negative regulation of DNA binding regulation of cell cycle osteoblast differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3400 15904 Ensembl ENSG00000172201 ENSMUSG00000021379 UniProt P47928 P41139 RefSeq (mRNA) NM_001546 NM_031166 RefSeq (protein) NP_001537 NP_112443 Location (UCSC) Chr 6: 19.84 – 19.84 Mb Chr 13: 48.41 – 48.42 Mb PubMed search [3] [4]
Wikidata
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ID4 is a protein coding gene. In humans, it encodes the protein known as DNA-binding protein inhibitor ID-4.^[5][6] This protein is known to be involved in the regulation of many cellular processes during both prenatal development and tumorigenesis. This is inclusive of embryonic cellular growth, senescence, cellular differentiation, apoptosis, and as an oncogene in angiogenesis.^[7]