IFITM1

IFITM1
Identifiers
Aliases	IFITM1, 9-27, CD225, DSPA2a, IFI17, LEU13, interferon induced transmembrane protein 1
External IDs	OMIM: 604456; HomoloGene: 74501; GeneCards: IFITM1; OMA:IFITM1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	315,272 bp
RNA expression pattern
	Top expressed in
	right ovary; ; granulocyte; ; canal of the cervix; ; left uterine tube; ; left ovary; ; right uterine tube; ; corpus epididymis; ; spleen; ; ectocervix; ; body of uterus;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; membrane; plasma membrane; protein-containing complex;
Biological process	negative regulation of viral entry into host cell; response to interferon-gamma; ossification; immune system process; response to virus; response to interferon-beta; response to biotic stimulus; cell surface receptor signaling pathway; negative regulation of viral genome replication; negative regulation of cell migration; positive regulation of osteoblast differentiation; defense response to virus; type I interferon signaling pathway; response to interferon-alpha; regulation of immune response; innate immune response; negative regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	8519
	n/a
	ENSG00000185885
	n/a
	P13164
	n/a
	NM_003641
	n/a
	NP_003632
	n/a
	Wikidata
View/Edit Human

Interferon-induced transmembrane protein 1 is a protein that in humans is encoded by the IFITM1 gene.^[3]^[4] IFITM1 has also recently been designated CD225 (cluster of differentiation 225). This protein has several additional names: fragilis (human homolog of the mouse protein), IFI17 [interferon-induced protein 17], 9-27 [Interferon-inducible protein 9-27] and Leu13.

IFITM1 is a member of the IFITM family (Interferon-induced transmembrane protein) which is encoded by IFITM genes. The human IFITM genes locate on chromosome 11 and have four members: IFITM1, IFITM2, IFITM3 and IFITM5.^[5] While the mouse Ifitm genes locate on chromosome 7 and 16 and have six members: Ifitm1, Ifitm2, Ifitm3, Ifitm5, Ifitm6 and Ifitm7.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185885 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Deblandre GA, Marinx OP, Evans SS, Majjaj S, Leo O, Caput D, Huez GA, Wathelet MG (Nov 1995). "Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth". J Biol Chem. 270 (40): 23860–6. doi:10.1074/jbc.270.40.23860. PMID 7559564.
^ "Entrez Gene: IFITM1 interferon induced transmembrane protein 1 (9-27)".
^ Hickford D, Frankenberg S, Shaw G, Renfree MB (2012). "Evolution of vertebrate interferon inducible transmembrane proteins". BMC Genomics. 13: 155. doi:10.1186/1471-2164-13-155. PMC 3424830. PMID 22537233.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185885 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7559564-3] Deblandre GA, Marinx OP, Evans SS, Majjaj S, Leo O, Caput D, Huez GA, Wathelet MG (Nov 1995). "Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth". J Biol Chem. 270 (40): 23860–6. doi:10.1074/jbc.270.40.23860. PMID 7559564.

[entrez-4] "Entrez Gene: IFITM1 interferon induced transmembrane protein 1 (9-27)".

[pmid22537233-5] Hickford D, Frankenberg S, Shaw G, Renfree MB (2012). "Evolution of vertebrate interferon inducible transmembrane proteins". BMC Genomics. 13: 155. doi:10.1186/1471-2164-13-155. PMC 3424830. PMID 22537233.

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