IL18RAP

IL18RAP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3WO4
Identifiers
Aliases	IL18RAP, ACPL, CD218b, CDw218b, IL-18R-beta, IL-18RAcP, IL-18Rbeta, IL-1R-7, IL-1R7, IL-1RAcPL, IL18RB, interleukin 18 receptor accessory protein
External IDs	OMIM: 604509; MGI: 1338888; HomoloGene: 2859; GeneCards: IL18RAP; OMA:IL18RAP - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	102,452,565 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	40,590,865 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; bone marrow; ; spleen; ; trabecular bone; ; right lung; ; bone marrow cells; ; upper lobe of left lung; ; periodontal fiber; ; appendix;
	Top expressed in
	granulocyte; ; blood; ; tibiofemoral joint; ; embryo; ; bone marrow; ; spleen; ; zygote; ; endothelial cell of lymphatic vessel; ; carotid body; ; subcutaneous adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling receptor activity; interleukin-18 receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; interleukin-18 receptor complex;
Biological process	cell surface receptor signaling pathway; inflammatory response; immune response; cellular response to cytokine stimulus; signal transduction; cellular response to hydrogen peroxide; cell population proliferation; interleukin-6 production; T-helper 1 cell cytokine production; neutrophil activation; positive regulation of natural killer cell mediated cytotoxicity; cellular response to interleukin-18; interleukin-18-mediated signaling pathway; positive regulation of NF-kappaB transcription factor activity;
	Sources:Amigo / QuickGO
Orthologs
	8807
	16174
	ENSG00000115607
	ENSMUSG00000026068
	O95256
	Q9Z2B1
	NM_003853
	NM_010553
	NP_003844
	NP_034683
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is a human gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115607 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026068 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: IL18RAP interleukin 18 receptor accessory protein".
^ Born TL, Thomassen E, Bird TA, Sims JE (November 1998). "Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling". J. Biol. Chem. 273 (45): 29445–50. doi:10.1074/jbc.273.45.29445. PMID 9792649.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115607 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026068 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez_8807-5] "Entrez Gene: IL18RAP interleukin 18 receptor accessory protein".

[pmid9792649-6] Born TL, Thomassen E, Bird TA, Sims JE (November 1998). "Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling". J. Biol. Chem. 273 (45): 29445–50. doi:10.1074/jbc.273.45.29445. PMID 9792649.

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