IL2RA

IL2RA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Z92, 2B5I, 2ERJ, 3IU3, 3NFP
Identifiers
Aliases	IL2RA, CD25, IDDM10, IL2R, TCGFR, p55, IMD41, interleukin 2 receptor subunit alpha
External IDs	OMIM: 147730; MGI: 96549; HomoloGene: 360; GeneCards: IL2RA; OMA:IL2RA - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	6,062,370 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	11,698,004 bp
RNA expression pattern
	Top expressed in
	lymph node; ; appendix; ; spleen; ; buccal mucosa cell; ; gallbladder; ; blood; ; granulocyte; ; epithelium of colon; ; smooth muscle tissue; ; tonsil;
	Top expressed in
	thymus; ; zygote; ; secondary oocyte; ; granulocyte; ; lymph node; ; muscle of thigh; ; blood; ; primary oocyte; ; sternocleidomastoid muscle; ; esophagus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	interleukin-2 receptor activity; interleukin-2 binding; protein binding;
Cellular component	integral component of membrane; membrane; plasma membrane; cell surface; external side of plasma membrane; intracellular anatomical structure; interleukin-2 receptor complex;
Biological process	Notch signaling pathway; positive regulation of T cell differentiation; regulation of T cell tolerance induction; inflammatory response to antigenic stimulus; negative regulation of defense response to virus; immune system process; activation-induced cell death of T cells; negative regulation of lymphocyte proliferation; MAPK cascade; T cell homeostasis; regulation of T cell homeostatic proliferation; cell surface receptor signaling pathway; negative regulation of T cell proliferation; negative regulation of immune response; immune response; positive regulation of T cell proliferation; cell population proliferation; inflammatory response; negative regulation of inflammatory response; positive regulation of activated T cell proliferation; apoptotic process; regulation of regulatory T cell differentiation; cytokine-mediated signaling pathway; interleukin-2-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3559
	16184
	ENSG00000134460
	ENSMUSG00000026770
	P01589
	P01590
	NM_000417; NM_001308242; NM_001308243
	NM_008367
	NP_000408; NP_001295171; NP_001295172
	NP_032393
	Wikidata
View/Edit Human	View/Edit Mouse

The Interleukin-2 receptor alpha chain (also called TAC antigen, P55, and mainly CD25) is a protein involved in the assembly of the high-affinity Interleukin-2 receptor, consisting of alpha (IL2RA), beta (IL2RB) and the common gamma chain (IL2RG). As the name indicates, this receptor interacts with Interleukin-2, a pleiotropic cytokine which plays an important role in immune homeostasis.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134460 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026770 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Spolski R, Li P, Leonard WJ (October 2018). "Biology and regulation of IL-2: from molecular mechanisms to human therapy". Nature Reviews. Immunology. 18 (10): 648–659. doi:10.1038/s41577-018-0046-y. PMID 30089912. S2CID 51939991.
^ Zhou P (October 2022). "Emerging mechanisms and applications of low-dose IL-2 therapy in autoimmunity". Cytokine & Growth Factor Reviews. 67: 80–88. doi:10.1016/j.cytogfr.2022.06.003. PMID 35803833. S2CID 250200065.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134460 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026770 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[:1-5] Spolski R, Li P, Leonard WJ (October 2018). "Biology and regulation of IL-2: from molecular mechanisms to human therapy". Nature Reviews. Immunology. 18 (10): 648–659. doi:10.1038/s41577-018-0046-y. PMID 30089912. S2CID 51939991.

[:5-6] Zhou P (October 2022). "Emerging mechanisms and applications of low-dose IL-2 therapy in autoimmunity". Cytokine & Growth Factor Reviews. 67: 80–88. doi:10.1016/j.cytogfr.2022.06.003. PMID 35803833. S2CID 250200065.

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