ITGAE

ITGAE
Identifiers
Aliases	ITGAE, CD103, HUMINAE, integrin subunit alpha E
External IDs	OMIM: 604682; MGI: 1298377; HomoloGene: 113560; GeneCards: ITGAE; OMA:ITGAE - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.2 Start 3,714,628 bp[1] End 3,801,188 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B4|11 45.22 cM Start 72,981,409 bp[2] End 73,038,272 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte glutes muscle of arm biceps brachii putamen triceps brachii muscle caudate nucleus monocyte lymph node Top expressed in seminiferous tubule spermatid spermatocyte mesenteric lymph nodes Paneth cell lumbar subsegment of spinal cord blood jejunum thymus duodenum More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding Cellular component integral component of membrane integrin complex plasma membrane external side of plasma membrane membrane Biological process integrin-mediated signaling pathway cell adhesion extracellular matrix organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3682 16407 Ensembl ENSG00000083457 ENSMUSG00000005947 UniProt P38570 Q60677 RefSeq (mRNA) NM_002208 NM_008399 NM_172944 NM_001361245 RefSeq (protein) NP_002199 NP_032425 NP_001348174 Location (UCSC) Chr 17: 3.71 – 3.8 Mb Chr 11: 72.98 – 73.04 Mb PubMed search [3] [4]
Wikidata
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Integrin, alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) is an integrin protein that in human is encoded by the ITGAE gene.^[5][6] CD103 binds integrin beta 7 (β7– ITGB7) to form the complete heterodimeric integrin molecule αEβ7, which has no distinct name. The αEβ7 complex is often referred to as "CD103" though this strictly refers only to the αE chain. Note that the β7 subunit can bind with other integrin α chains, such as α4 (CD49d).