Integrase Zinc binding domain | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
Symbol | Integrase_Zn | ||||||||
Pfam | PF02022 | ||||||||
InterPro | IPR003308 | ||||||||
SCOP2 | 1wjb / SCOPe / SUPFAM | ||||||||
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Integrase core domain | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
Symbol | rve | ||||||||
Pfam | PF00665 | ||||||||
Pfam clan | CL0219 | ||||||||
InterPro | IPR001584 | ||||||||
SCOP2 | 2itg / SCOPe / SUPFAM | ||||||||
|
Integrase DNA binding domain | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
Symbol | IN_DBD_C | ||||||||
Pfam | PF00552 | ||||||||
InterPro | IPR001037 | ||||||||
SCOP2 | 1ihw / SCOPe / SUPFAM | ||||||||
|
Retroviral integrase (IN) is an enzyme produced by a retrovirus (such as HIV) that integrates (forms covalent links between) its genetic information into that of the host cell it infects.[1] Retroviral INs are not to be confused with phage integrases (recombinases) used in biotechnology, such as λ phage integrase, as discussed in site-specific recombination.
The macromolecular complex of an IN macromolecule bound to the ends of the viral DNA ends has been referred to as the intasome; IN is a key component in this and the retroviral pre-integration complex.[2]
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