Integrin alpha 6

ITGA6
Identifiers
Aliases	ITGA6, CD49f, ITGA6B, VLA-6, integrin subunit alpha 6, JEB6
External IDs	OMIM: 147556; MGI: 96605; HomoloGene: 20091; GeneCards: ITGA6; OMA:ITGA6 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	172,506,459 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	71,688,760 bp
RNA expression pattern
	Top expressed in
	tibial nerve; ; sural nerve; ; spinal ganglia; ; trigeminal ganglion; ; epithelium of colon; ; Achilles tendon; ; rectum; ; pylorus; ; tendon of biceps brachii; ; duodenum;
	Top expressed in
	sciatic nerve; ; epithelium of stomach; ; secondary oocyte; ; atrium; ; epithelium of lens; ; left lung lobe; ; crypt of lieberkuhn of small intestine; ; endothelial cell of lymphatic vessel; ; pyloric antrum; ; left colon;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; integrin binding; protein binding; laminin binding; neuregulin binding; protein-containing complex binding; insulin-like growth factor I binding; cadherin binding;
Cellular component	integral component of membrane; membrane; focal adhesion; basal part of cell; plasma membrane; hemidesmosome; basement membrane; cell surface; integrin complex; basal plasma membrane; basolateral plasma membrane; external side of plasma membrane; integrin alpha6-beta4 complex; filopodium;
Biological process	cellular response to extracellular stimulus; hemidesmosome assembly; renal system development; nail development; positive regulation of cell-cell adhesion; filopodium assembly; negative regulation of extrinsic apoptotic signaling pathway; extracellular matrix organization; odontogenesis of dentin-containing tooth; cell-substrate adhesion; positive regulation of GTPase activity; cell adhesion; cell adhesion mediated by integrin; brown fat cell differentiation; positive regulation of apoptotic process; cell-substrate junction assembly; integrin-mediated signaling pathway; positive regulation of phosphorylation; cell-matrix adhesion; digestive tract development; ectodermal cell differentiation; leukocyte migration; skin development; positive regulation of transcription by RNA polymerase II; amelogenesis; cellular response to organic cyclic compound; positive regulation of cell-substrate adhesion; positive regulation of cell migration; cell-cell adhesion; positive regulation of neuron projection development;
	Sources:Amigo / QuickGO
Orthologs
	3655
	16403
	ENSG00000091409
	ENSMUSG00000027111
	P23229
	Q61739
NM_000210; NM_001079818; NM_001316306; NM_001365529; NM_001365530;
	NM_001394928
	NM_001277970; NM_008397
	NP_000201; NP_001073286; NP_001303235; NP_001352458; NP_001352459
	NP_001264899; NP_032423; NP_001393187
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000091409 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027111 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000091409 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027111 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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