Interleukin-17 receptor

interleukin 17 receptor A
Crystal structure of a complex of IL-17RA bound to IL-17F in a 1:2 stoichiometry.[1]
Identifiers
Symbol	IL17RA
Alt. symbols	IL17R, CDw217
NCBI gene	23765
HGNC	5985
OMIM	605461
RefSeq	NM_014339
UniProt	Q96F46
Other data
Locus	Chr. 22 q11.1
Search for Structures Swiss-model Domains InterPro

Interleukin-17 receptor (IL-17R) is a cytokine receptor which belongs to new subfamily of receptors binding proinflammatory cytokine interleukin 17A, a member of IL-17 family ligands produced by T helper 17 cells (Th17).^[2] IL-17R family consists of 5 members: IL-17RA, IL-17RB, IL-17RC, IL-17RD and IL-17RE. Functional IL-17R is a transmembrane receptor complex usually consisting of one IL-17RA, which is a founding member of the family, and second other family subunit, thus forming heteromeric receptor binding different ligands. IL-17A, a founding member of IL-17 ligand family binds to heteromeric IL-17RA/RC receptor complex.^[3] IL-17RB binds preferentially IL-17B and IL-17E^[4][5] and heteromeric IL-17RA/RE complex binds IL-17C. However, there is still unknown ligand for IL-17RD. The first identified member IL-17RA is located on human chromosome 22, whereas other subunits IL-17RB to IL-17RD are encoded within human chromosome 3.