Interleukin-4 receptor

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Interleukin-4 receptor alpha chain, N-terminal
Interleukin-4 receptor alpha chain, N-terminal
	interleukin-4 / receptor alpha chain complex
Identifiers
Symbol	IL4Ra_N
Pfam	PF09238
InterPro	IPR015319
SCOP2	1iar / SCOPe / SUPFAM
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

IL4R
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IAR, 1IRS, 3BPL, 3BPN, 3BPO, 5E4E
Identifiers
Aliases	IL4R, CD124, IL-4RA, IL4RA, Interleukin-4 receptor, interleukin 4 receptor
External IDs	OMIM: 147781; MGI: 105367; HomoloGene: 7784; GeneCards: IL4R; OMA:IL4R - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	27,364,778 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	125,178,646 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; right lung; ; gastric mucosa; ; upper lobe of left lung; ; muscle layer of sigmoid colon; ; appendix; ; spleen; ; transverse colon; ; right lobe of liver; ; lymph node;
	Top expressed in
	lumbar spinal ganglion; ; stroma of bone marrow; ; granulocyte; ; mesenteric lymph nodes; ; thymus; ; ankle joint; ; uterus; ; right lung lobe; ; spleen; ; ileum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; cytokine receptor activity; interleukin-4 receptor activity;
Cellular component	integral component of membrane; membrane; receptor complex; integral component of plasma membrane; extracellular region; extracellular space; plasma membrane;
Biological process	immune system process; positive regulation of immunoglobulin production; positive regulation of macrophage activation; positive regulation of mast cell degranulation; response to estrogen; production of molecular mediator involved in inflammatory response; positive regulation of myoblast fusion; negative regulation of T-helper 1 cell differentiation; regulation of cell population proliferation; immunoglobulin mediated immune response; immune response; positive regulation of T-helper 2 cell differentiation; ovulation; signal transduction; defense response to protozoan; interleukin-4-mediated signaling pathway; response to odorant; cytokine-mediated signaling pathway; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	3566
	16190
	ENSG00000077238
	ENSMUSG00000030748
	P24394
	P16382
	NM_000418; NM_001008699; NM_001257406; NM_001257407; NM_001257997
	NM_001008700; NM_001363983
	NP_000409; NP_001244335; NP_001244336; NP_001244926
	NP_001008700; NP_001350912
	Wikidata
View/Edit Human	View/Edit Mouse

The interleukin 4 receptor is a type I cytokine receptor. It is a heterodimer, that is, composed of two subunits. IL4R is the human gene coding for IL-4Rα, the subunit which combines with either common gamma chain (γc, forming the type I IL4 receptor) or with IL-13Rα1 (forming the type II IL4 receptor).^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000077238 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030748 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McCormick SM (14 July 2015). "Commentary: IL-4 and IL-13 receptors and signaling". Cytokine. 75 (1): 38–50. doi:10.1016/j.cyto.2015.05.023. PMC 4546937. PMID 26187331 – via Elsevier ScienceDirect.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000077238 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030748 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] McCormick SM (14 July 2015). "Commentary: IL-4 and IL-13 receptors and signaling". Cytokine. 75 (1): 38–50. doi:10.1016/j.cyto.2015.05.023. PMC 4546937. PMID 26187331 – via Elsevier ScienceDirect.

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