Interleukin-6 receptor

IL6R
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1N26, 1P9M, 2ARW
Identifiers
Aliases	IL6R, CD126, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, gp80, Interleukin-6 receptor, interleukin 6 receptor
External IDs	OMIM: 147880; MGI: 105304; HomoloGene: 474; GeneCards: IL6R; OMA:IL6R - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	154,469,450 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	89,820,503 bp
RNA expression pattern
	Top expressed in
	blood; ; monocyte; ; right lobe of liver; ; gastrocnemius muscle; ; granulocyte; ; trabecular bone; ; bone marrow cells; ; synovial joint; ; saphenous vein; ; gastric mucosa;
	Top expressed in
	granulocyte; ; blood; ; islet of Langerhans; ; decidua; ; muscle of thigh; ; lip; ; left lobe of liver; ; tibiofemoral joint; ; esophagus; ; lymph node;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	ciliary neurotrophic factor receptor activity; protein homodimerization activity; interleukin-6 receptor binding; protein binding; cytokine receptor activity; enzyme binding; ciliary neurotrophic factor binding; interleukin-6 receptor activity; interleukin-6 binding; interleukin-12 receptor binding; growth factor activity; cytokine binding; interleukin-12 alpha subunit binding; interleukin-23 receptor binding;
Cellular component	integral component of membrane; membrane; plasma membrane; extracellular region; basolateral plasma membrane; apical plasma membrane; interleukin-6 receptor complex; ciliary neurotrophic factor receptor complex; extracellular space; cell surface; external side of plasma membrane; receptor complex; interleukin-12 complex; interleukin-23 complex;
Biological process	positive regulation of activation of Janus kinase activity; response to cytokine; hepatic immune response; extrinsic apoptotic signaling pathway; monocyte chemotaxis; ciliary neurotrophic factor-mediated signaling pathway; positive regulation of leukocyte chemotaxis; negative regulation of interleukin-8 production; positive regulation of osteoblast differentiation; defense response to Gram-negative bacterium; acute-phase response; positive regulation of NF-kappaB transcription factor activity; positive regulation of cell population proliferation; positive regulation of interleukin-6 production; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of chemokine production; neutrophil mediated immunity; negative regulation of collagen biosynthetic process; endocrine pancreas development; positive regulation of MAPK cascade; positive regulation of smooth muscle cell proliferation; defense response to Gram-positive bacterium; positive regulation of tyrosine phosphorylation of STAT protein; cytokine-mediated signaling pathway; interleukin-6-mediated signaling pathway; positive regulation of T-helper 1 type immune response; regulation of signaling receptor activity; positive regulation of interferon-gamma production; positive regulation of natural killer cell activation; positive regulation of activated T cell proliferation; positive regulation of lymphocyte proliferation; positive regulation of NK T cell activation; positive regulation of glomerular mesangial cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	3570
	16194
	ENSG00000160712
	ENSMUSG00000027947
	P08887
	P22272
	NM_000565; NM_001206866; NM_181359
	NM_010559; NM_001310676
NP_000556; NP_001193795; NP_852004; NP_001369698; NP_001369699;
	NP_001369700; NP_001369701; NP_001369702; NP_001369703
	NP_001297605; NP_034689
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 6 receptor (IL6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160712 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027947 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160712 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027947 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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