Interleukin 13

IL13
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GA3, 1IJZ, 1IK0, 3BPO, 3G6D, 3L5W, 3L5X, 3LB6, 4I77, 4PS4, 5E4E
Identifiers
Aliases	IL13, IL-13, P600, interleukin 13
External IDs	OMIM: 147683; MGI: 96541; HomoloGene: 1649; GeneCards: IL13; OMA:IL13 - orthologs
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	53,525,529 bp
RNA expression pattern
	n/a
	Top expressed in
	embryo; ; secondary oocyte; ; zygote; ; seminiferous tubule; ; thymus; ; spermatocyte; ; hippocampal formation; ; hippocampus proper; ; lip; ; spermatid;
	More reference expression data
Gene ontology
Molecular function	protein binding; cytokine receptor binding; cytokine activity; interleukin-13 receptor binding;
Cellular component	cytoplasm; external side of plasma membrane; extracellular region; extracellular space;
Biological process	negative regulation of endothelial cell apoptotic process; negative regulation of complement-dependent cytotoxicity; negative regulation of transforming growth factor beta production; positive regulation of lung goblet cell differentiation; response to mechanical stimulus; response to nicotine; positive regulation of release of sequestered calcium ion into cytosol; microglial cell activation; negative regulation of NAD(P)H oxidase activity; cellular response to mechanical stimulus; response to lipopolysaccharide; negative regulation of lung ciliated cell differentiation; positive regulation of ion transport; immune response; positive regulation of protein secretion; positive regulation of connective tissue growth factor production; positive regulation of pancreatic stellate cell proliferation; response to ethanol; inflammatory response; regulation of proton transport; positive regulation of smooth muscle cell proliferation; negative regulation of neuron death; positive regulation of immunoglobulin production; positive regulation of B cell proliferation; positive regulation of macrophage activation; positive regulation of mast cell degranulation; cellular response to cytokine stimulus; positive regulation of tyrosine phosphorylation of STAT protein; regulation of signaling receptor activity; cytokine-mediated signaling pathway; positive regulation of gene expression; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	3596
	16163
	ENSG00000169194
	ENSMUSG00000020383
	P35225
	P20109
	NM_002188
	NM_008355
	NP_002179; NP_001341920; NP_001341921; NP_001341922
	NP_032381
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene.^[4]^[5]^[6] IL-13 was first cloned in 1993 and is located on chromosome 5q31.1 with a length of 1.4kb.^[4] It has a mass of 13 kDa and folds into 4 alpha helical bundles.^[7] The secondary structural features of IL-13 are similar to that of Interleukin 4 (IL-4); however it only has 25% sequence identity to IL-4 and is capable of IL-4 independent signaling.^[7]^[4]^[8] IL-13 is a cytokine secreted by T helper type 2 (Th2) cells, CD4 cells, natural killer T cell, mast cells, basophils, eosinophils and nuocytes.^[7] Interleukin-13 is a central regulator in IgE synthesis, goblet cell hyperplasia, mucus hypersecretion, airway hyperresponsiveness, fibrosis and chitinase up-regulation.^[7] It is a mediator of allergic inflammation and different diseases including asthma.^[7], and atopic dermatitis.^[9]

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020383 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c Minty A, Chalon P, Derocq JM, Dumont X, Guillemot JC, Kaghad M, et al. (March 1993). "Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses". Nature. 362 (6417): 248–250. Bibcode:1993Natur.362..248M. doi:10.1038/362248a0. PMID 8096327. S2CID 4368915.
^ McKenzie AN, Culpepper JA, de Waal Malefyt R, Brière F, Punnonen J, Aversa G, et al. (April 1993). "Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function". Proceedings of the National Academy of Sciences of the United States of America. 90 (8): 3735–3739. Bibcode:1993PNAS...90.3735M. doi:10.1073/pnas.90.8.3735. PMC 46376. PMID 8097324.
^ Morgan JG, Dolganov GM, Robbins SE, Hinton LM, Lovett M (October 1992). "The selective isolation of novel cDNAs encoded by the regions surrounding the human interleukin 4 and 5 genes". Nucleic Acids Research. 20 (19): 5173–5179. doi:10.1093/nar/20.19.5173. PMC 334302. PMID 1408833.
^ ^a ^b ^c ^d ^e Rael EL, Lockey RF (March 2011). "Interleukin-13 signaling and its role in asthma". The World Allergy Organization Journal. 4 (3): 54–64. doi:10.1097/WOX.0b013e31821188e0. PMC 3651056. PMID 23283176.
^ Zurawski G, de Vries JE (January 1994). "Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells". Immunology Today. 15 (1): 19–26. doi:10.1016/0167-5699(94)90021-3. PMID 7907877.
^ Dekkers C, de Bruin-Weller M (2024). "The pleiotropic role of IL-13 in AD pathogenesis". The British Journal of Dermatology. 15 (1): 19–26. doi:10.1093/bjd/ljae174. PMID 38659397.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000020383 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8096327-4] Minty A, Chalon P, Derocq JM, Dumont X, Guillemot JC, Kaghad M, et al. (March 1993). "Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses". Nature. 362 (6417): 248–250. Bibcode:1993Natur.362..248M. doi:10.1038/362248a0. PMID 8096327. S2CID 4368915.

[pmid8097324-5] McKenzie AN, Culpepper JA, de Waal Malefyt R, Brière F, Punnonen J, Aversa G, et al. (April 1993). "Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function". Proceedings of the National Academy of Sciences of the United States of America. 90 (8): 3735–3739. Bibcode:1993PNAS...90.3735M. doi:10.1073/pnas.90.8.3735. PMC 46376. PMID 8097324.

[pmid1408833-6] Morgan JG, Dolganov GM, Robbins SE, Hinton LM, Lovett M (October 1992). "The selective isolation of novel cDNAs encoded by the regions surrounding the human interleukin 4 and 5 genes". Nucleic Acids Research. 20 (19): 5173–5179. doi:10.1093/nar/20.19.5173. PMC 334302. PMID 1408833.

[ma831-7] Rael EL, Lockey RF (March 2011). "Interleukin-13 signaling and its role in asthma". The World Allergy Organization Journal. 4 (3): 54–64. doi:10.1097/WOX.0b013e31821188e0. PMC 3651056. PMID 23283176.

[pmid7907877-8] Zurawski G, de Vries JE (January 1994). "Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells". Immunology Today. 15 (1): 19–26. doi:10.1016/0167-5699(94)90021-3. PMID 7907877.

[pmid38659397-9] Dekkers C, de Bruin-Weller M (2024). "The pleiotropic role of IL-13 in AD pathogenesis". The British Journal of Dermatology. 15 (1): 19–26. doi:10.1093/bjd/ljae174. PMID 38659397.

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