Interleukin 3

IL3
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1JLI
Identifiers
Aliases	IL3, interleukin 3, IL-3, MCGF, MULTI-CSF
External IDs	OMIM: 147740; HomoloGene: 47938; GeneCards: IL3; OMA:IL3 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	132,063,204 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; bone marrow; ; lymph node; ; appendix;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	growth factor activity; interleukin-3 receptor binding; cytokine activity; protein tyrosine kinase activity; interleukin-1 receptor binding;
Cellular component	extracellular region; intracellular anatomical structure; extracellular space;
Biological process	MAPK cascade; embryonic hemopoiesis; cell-cell signaling; nervous system development; positive regulation of peptidyl-tyrosine phosphorylation; immune response; peptidyl-tyrosine phosphorylation; positive regulation of tyrosine phosphorylation of STAT protein; fever generation; regulation of cytokine-mediated signaling pathway; regulation of signaling receptor activity; cytokine-mediated signaling pathway; positive regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	3562
	n/a
	ENSG00000164399
	n/a
	P08700
	n/a
	NM_000588
	n/a
	NP_000579
	n/a
	Wikidata
View/Edit Human

Interleukin 3 (IL-3) is a protein that in humans is encoded by the IL3 gene localized on chromosome 5q31.1.^[3]^[4] Sometimes also called colony-stimulating factor, multi-CSF, mast cell growth factor, MULTI-CSF, MCGF; MGC79398, MGC79399: after removal of the signal peptide sequence, the mature protein contains 133 amino acids in its polypeptide chain. IL-3 is produced as a monomer by activated T cells, monocytes/macrophages and stroma cells.^[5] The major function of IL-3 cytokine is to regulate the concentrations of various blood-cell types.^[6] It induces proliferation and differentiation in both early pluripotent stem cells and committed progenitors.^[7]^[8] It also has many more specific effects like the regeneration of platelets and potentially aids in early antibody isotype switching.^[9]^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164399 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: IL3 interleukin 3 (colony-stimulating factor, multiple)".
^ Yang YC, Ciarletta AB, Temple PA, Chung MP, Kovacic S, Witek-Giannotti JS, Leary AC, Kriz R, Donahue RE, Wong GG (October 1986). "Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3". Cell. 47 (1): 3–10. doi:10.1016/0092-8674(86)90360-0. PMID 3489530. S2CID 37207637.
^ "IL3 (interleukin-3)". atlasgeneticsoncology.org. Archived from the original on 2022-02-05. Retrieved 2019-06-19.
^ Aiguo W, Guangren D (July 2006). "PMID Observer Design of Descriptor Linear Systems". 2007 Chinese Control Conference. IEEE. pp. 161–165. doi:10.1109/chicc.2006.4347343. ISBN 978-7-81124-055-9. S2CID 72187.
^ Aglietta M, Pasquino P, Sanavio F, Stacchini A, Severino A, Fubini L, Morelli S, Volta C, Monteverde A (1996-01-01). "Granulocyte-Macrophage colony stimulating factor and interleukin 3: Target cells and kinetics of response in vivo". Stem Cells. 11 (S2): 83–87. doi:10.1002/stem.5530110814. ISSN 1066-5099. PMID 8401260. S2CID 27772987.
^ Guthridge MA, Stomski FC, Thomas D, Woodcock JM, Bagley CJ, Berndt MC, Lopez AF (September 1998). "Mechanism of Activation of the GM-CSF, IL-3, and IL-5 Family of Receptors". Stem Cells. 16 (5): 301–313. doi:10.1002/stem.160301. ISSN 1066-5099. PMID 9766809.
^ Wang AA, Gommerman JL, Rojas OL (January 2021). "Plasma Cells: From Cytokine Production to Regulation in Experimental Autoimmune Encephalomyelitis". Journal of Molecular Biology. 433 (1): 166655. doi:10.1016/j.jmb.2020.09.014. ISSN 0022-2836. PMID 32976908.
^ Dougan M, Dranoff G, Dougan SK (April 2019). "GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation". Immunity. 50 (4): 796–811. doi:10.1016/j.immuni.2019.03.022. ISSN 1074-7613. PMID 30995500.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164399 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: IL3 interleukin 3 (colony-stimulating factor, multiple)".

[pmid3489530-4] Yang YC, Ciarletta AB, Temple PA, Chung MP, Kovacic S, Witek-Giannotti JS, Leary AC, Kriz R, Donahue RE, Wong GG (October 1986). "Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3". Cell. 47 (1): 3–10. doi:10.1016/0092-8674(86)90360-0. PMID 3489530. S2CID 37207637.

[IL3_interleukin-3-5] "IL3 (interleukin-3)". atlasgeneticsoncology.org. Archived from the original on 2022-02-05. Retrieved 2019-06-19.

[Aiguo_161–165-6] Aiguo W, Guangren D (July 2006). "PMID Observer Design of Descriptor Linear Systems". 2007 Chinese Control Conference. IEEE. pp. 161–165. doi:10.1109/chicc.2006.4347343. ISBN 978-7-81124-055-9. S2CID 72187.

[7] Aglietta M, Pasquino P, Sanavio F, Stacchini A, Severino A, Fubini L, Morelli S, Volta C, Monteverde A (1996-01-01). "Granulocyte-Macrophage colony stimulating factor and interleukin 3: Target cells and kinetics of response in vivo". Stem Cells. 11 (S2): 83–87. doi:10.1002/stem.5530110814. ISSN 1066-5099. PMID 8401260. S2CID 27772987.

[:2-8] Guthridge MA, Stomski FC, Thomas D, Woodcock JM, Bagley CJ, Berndt MC, Lopez AF (September 1998). "Mechanism of Activation of the GM-CSF, IL-3, and IL-5 Family of Receptors". Stem Cells. 16 (5): 301–313. doi:10.1002/stem.160301. ISSN 1066-5099. PMID 9766809.

[:3-9] Wang AA, Gommerman JL, Rojas OL (January 2021). "Plasma Cells: From Cytokine Production to Regulation in Experimental Autoimmune Encephalomyelitis". Journal of Molecular Biology. 433 (1): 166655. doi:10.1016/j.jmb.2020.09.014. ISSN 0022-2836. PMID 32976908.

[:4-10] Dougan M, Dranoff G, Dougan SK (April 2019). "GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation". Immunity. 50 (4): 796–811. doi:10.1016/j.immuni.2019.03.022. ISSN 1074-7613. PMID 30995500.

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