Interleukin 4

IL4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BBN, 1BCN, 1CYL, 1HIJ, 1HIK, 1HZI, 1IAR, 1ITI, 1ITL, 1ITM, 1RCB, 2B8U, 2B8X, 2B8Y, 2B8Z, 2B90, 2B91, 2CYK, 2D48, 2INT, 3BPL, 3BPN, 3QB7, 4YDY, 5FHX
Identifiers
Aliases	IL4, Interleukin 4, IL-4
External IDs	MGI: 96556; HomoloGene: 491; GeneCards: IL4; OMA:IL4 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q31.1 Start 132,009,678 bp End 132,018,370 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse)[1] Band 11 B1.3|11 31.97 cM Start 53,493,809 bp[1] End 53,509,496 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte testicle gonad right uterine tube monocyte anterior pituitary right coronary artery olfactory zone of nasal mucosa bone marrow cells Top expressed in neural layer of retina superior frontal gyrus spermatocyte primary visual cortex lens embryo embryo dentate gyrus of hippocampal formation granule cell ventricular zone morula More reference expression data BioGPS n/a
Gene ontology Molecular function interleukin-4 receptor binding protein binding growth factor activity cytokine receptor binding cytokine activity Cellular component extracellular region extracellular space Biological process positive regulation of T cell differentiation dendritic cell differentiation negative regulation of endothelial cell apoptotic process negative regulation of complement-dependent cytotoxicity regulation of phosphorylation negative regulation of apoptotic process myeloid dendritic cell differentiation type 2 immune response B cell activation positive regulation of interleukin-13 production immune response B cell differentiation T-helper 2 cell cytokine production regulation of isotype switching negative regulation of transcription, DNA-templated negative regulation of epithelial cell migration regulation of signaling receptor activity cholesterol metabolic process positive regulation of B cell proliferation positive regulation of T cell proliferation T cell activation positive regulation of MHC class II biosynthetic process negative regulation of osteoclast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of isotype switching to IgE isotypes positive regulation of isotype switching to IgG isotypes regulation of immune response cytokine-mediated signaling pathway positive regulation of gene expression positive regulation of macroautophagy positive regulation of tyrosine phosphorylation of STAT protein activation of Janus kinase activity positive regulation of receptor-mediated endocytosis positive regulation of cold-induced thermogenesis negative regulation of neuroinflammatory response positive regulation of amyloid-beta clearance neuroinflammatory response positive regulation of cellular respiration positive regulation of ATP biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3565 16189 Ensembl ENSG00000113520 ENSMUSG00000000869 UniProt P05112 P07750 RefSeq (mRNA) NM_000589.4 NM_021283 RefSeq (protein) NP_000580 NP_758858 NP_001341919 NP_067258 Location (UCSC) Chr 5: 132.01 – 132.02 Mb Chr 11: 53.49 – 53.51 Mb PubMed search [2] [3]
Wikidata
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Interleukin 4
analysis of the solution structure of human interleukin 4 determined by heteronuclear three-dimensional nuclear magnetic resonance techniques
Identifiers
Symbol	IL4
Pfam	PF00727
Pfam clan	CL0053
InterPro	IPR002354
PROSITE	PDOC00655
SCOP2	2int / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (T_h0 cells) to T_h2 cells. Upon activation by IL-4, T_h2 cells subsequently produce additional IL-4 in a positive feedback loop. IL-4 is produced primarily by mast cells, T_h2 cells, eosinophils and basophils.^[4] It is closely related and has functions similar to IL-13.