Interleukin 8 receptor, beta

CXCR2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4Q3H
Identifiers
Aliases	CXCR2, CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB, Interleukin 8 receptor, beta, C-X-C motif chemokine receptor 2, WHIMS2
External IDs	OMIM: 146928; MGI: 105303; HomoloGene: 10439; GeneCards: CXCR2; OMA:CXCR2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	218,137,251 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	74,200,405 bp
RNA expression pattern
	Top expressed in
	blood; ; periodontal fiber; ; granulocyte; ; trabecular bone; ; epithelium of esophagus; ; monocyte; ; gonad; ; spleen; ; oral cavity; ; bone marrow;
	Top expressed in
	granulocyte; ; placenta; ; bone marrow; ; esophagus; ; embryo; ; spleen; ; embryo; ; blastocyst; ; lip; ; lung;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	C-X-C chemokine receptor activity; interleukin-8 binding; protein binding; interleukin-8 receptor activity; chemokine receptor activity; signal transducer activity; G protein-coupled receptor activity; C-C chemokine receptor activity; chemokine binding; C-C chemokine binding;
Cellular component	integral component of membrane; membrane; mast cell granule; plasma membrane; integral component of plasma membrane; intracellular anatomical structure; cell surface; secretory granule membrane; external side of plasma membrane;
Biological process	neutrophil activation; receptor internalization; dendritic cell chemotaxis; chemotaxis; cellular defense response; phospholipase C-activating G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; positive regulation of cell population proliferation; inflammatory response; chemokine-mediated signaling pathway; neutrophil degranulation; G protein-coupled receptor signaling pathway; acute inflammatory response to antigenic stimulus; positive regulation of leukocyte chemotaxis; positive regulation of cytosolic calcium ion concentration; positive regulation of cardiac muscle cell apoptotic process; neutrophil chemotaxis; midbrain development; negative regulation of neutrophil apoptotic process; negative regulation of apoptotic process; positive regulation of vascular permeability; positive regulation of angiogenesis; metanephric tubule morphogenesis; positive regulation of neutrophil chemotaxis; signal transduction; interleukin-8-mediated signaling pathway; immune response; calcium-mediated signaling; cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	3579
	12765
	ENSG00000180871
	ENSMUSG00000026180
	P25025
	P35343
	NM_001168298; NM_001557
	NM_009909
	NP_001161770; NP_001548
	NP_034039
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 8 receptor, beta is a chemokine receptor. IL8RB is also known as CXCR2, and CXCR2 is now the IUPHAR Committee on Receptor Nomenclature and Drug classification-recommended name.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000180871 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026180 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Morris SW, Nelson N, Valentine MB, Shapiro DN, Look AT, Kozlosky CJ, Beckmann MP, Cerretti DP (Nov 1992). "Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35". Genomics. 14 (3): 685–91. doi:10.1016/S0888-7543(05)80169-7. PMID 1427896.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000180871 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026180 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1427896-5] Morris SW, Nelson N, Valentine MB, Shapiro DN, Look AT, Kozlosky CJ, Beckmann MP, Cerretti DP (Nov 1992). "Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35". Genomics. 14 (3): 685–91. doi:10.1016/S0888-7543(05)80169-7. PMID 1427896.

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