Intrahepatic cholestasis of pregnancy

Intrahepatic cholestasis of pregnancy
High magnification micrograph showing liver cholestasis.
Specialty	Obstetrics

Intrahepatic cholestasis of pregnancy (ICP), also known as obstetric cholestasis, cholestasis of pregnancy, jaundice of pregnancy, and prurigo gravidarum,^[1] is a medical condition in which cholestasis occurs during pregnancy.^[2] It typically presents with itching and can lead to complications for both mother and fetus.^[2]

Itching is a common symptom of pregnancy, affecting around 23% of women.^[3] The majority of times, itching is a minor annoyance caused by changes to the skin, especially that of the abdomen. However, there are instances when itching may be a symptom of ICP. Although typically noticed on the palms of the hands and the soles of the feet, the itching can occur anywhere on the body.

Onset is mostly in the third trimester, but may begin earlier.^[4]