Issaquena County, Mississippi

Issaquena County
County
Historic photo of the Issaquena County Courthouse in Mayersville, Mississippi
Location within the U.S. state of Mississippi
Mississippi's location within the U.S.
Coordinates: 32°44′N 90°59′W / 32.74°N 90.99°W / 32.74; -90.99
Country	United States
State	Mississippi
Founded	January 23, 1844
Seat	Mayersville
Largest town	Mayersville
Area
• Total	441 sq mi (1,140 km2)
• Land	413 sq mi (1,070 km2)
• Water	28 sq mi (70 km2)  6.4%
Population  (2020)
• Total	1,338
• Estimate  (2022)	1,273
• Density	3.0/sq mi (1.2/km2)
Time zone	UTC−6 (Central)
• Summer (DST)	UTC−5 (CDT)
Congressional district	2nd

Issaquena County (/ˌɪsəˈkwiːnə/, ISS-ə-KWEEN-ə) is a county located in the U.S. state of Mississippi. As of the 2020 Census, its population was 1,338,^[1] making it the least populous county in the United States east of the Mississippi River. Its county seat is Mayersville.^[2] With a per-capita income of $18,598, Issaquena County is, by that measure, one of the poorest counties in the United States.^{[citation needed]}

Issaquena County is located in the Mississippi Delta region. The Mississippi River flows along the entire western boundary of the county, and many of the earliest communities were river ports.

The county's economy is chiefly based on agriculture, though a number of hunting camps are also located here and contribute to the economy. Mississippi's two most recent records for the heaviest alligator taken by a hunter have both been in Issaquena County, the latest in 2012 when a 697.5 lb (316.4 kg) alligator was killed at a camp near Fitler.^[3]