LAMP2

LAMP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MOF, 2MOM
Identifiers
Aliases	LAMP2, CD107b, LAMP-2, LAMPB, LGP110, lysosomal associated membrane protein 2, LGP-96, DND
External IDs	OMIM: 309060; MGI: 96748; HomoloGene: 7809; GeneCards: LAMP2; OMA:LAMP2 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq24 Start 120,426,148 bp[1] End 120,469,365 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X A3.3|X 22.67 cM Start 37,490,234 bp[2] End 37,545,331 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum external globus pallidus kidney tubule parotid gland gallbladder inferior ganglion of vagus nerve stromal cell of endometrium C1 segment gingival epithelium pars reticulata Top expressed in ciliary body iris Epithelium of choroid plexus conjunctival fornix vestibular sensory epithelium aortic valve right kidney hair follicle stroma of bone marrow molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein domain specific binding protein binding enzyme binding Cellular component integral component of membrane membrane microdomain endosome late endosome phagocytic vesicle membrane chaperone-mediated autophagy translocation complex membrane late endosome membrane plasma membrane lysosomal membrane lysosomal lumen platelet dense granule membrane lysosome endosome membrane extracellular exosome autophagosome membrane extracellular space trans-Golgi network cytoplasmic vesicle azurophil granule membrane autolysosome perinuclear region of cytoplasm integral component of autophagosome membrane ficolin-1-rich granule membrane membrane raft lysosomal matrix Biological process regulation of protein stability muscle cell cellular homeostasis protein stabilization platelet degranulation protein import protein targeting autophagy cellular response to starvation negative regulation of protein homooligomerization neutrophil degranulation chaperone-mediated autophagy protein targeting to lysosome involved in chaperone-mediated autophagy autophagosome maturation lysosomal protein catabolic process establishment of protein localization to organelle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3920 16784 Ensembl ENSG00000005893 ENSMUSG00000016534 UniProt P13473 P17047 RefSeq (mRNA) NM_013995 NM_001122606 NM_002294 NM_001017959 NM_001290485 NM_010685 RefSeq (protein) NP_001116078 NP_002285 NP_054701 NP_001017959 NP_001277414 NP_034815 Location (UCSC) Chr X: 120.43 – 120.47 Mb Chr X: 37.49 – 37.55 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Lysosome-associated membrane protein 2 (LAMP2), also known as CD107b (Cluster of Differentiation 107b) and Mac-3, is a human gene. Its protein, LAMP2, is one of the lysosome-associated membrane glycoproteins.

The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of the gene produces three variants - LAMP-2A, LAMP-2B and LAMP-2C.^[5] LAMP-2A is the receptor for chaperone-mediated autophagy. Recently it has been determined that antibodies against LAMP-2 account for a fraction of patients who get a serious kidney disease termed focal necrotizing glomerulonephritis.

LAMP-2B is associated with Danon disease.