LIGHT (protein)

TNFSF14
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4EN0, 4J6G, 4KG8, 4KGG, 4KGQ, 4RSU
Identifiers
Aliases	TNFSF14, CD258, HVEML, LIGHT, LTg, TR2, TNLG1D, tumor necrosis factor superfamily member 14, TNF superfamily member 14
External IDs	OMIM: 604520; MGI: 1355317; HomoloGene: 2822; GeneCards: TNFSF14; OMA:TNFSF14 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	6,670,588 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	57,501,177 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; blood; ; pericardium; ; parietal pleura; ; granulocyte; ; amniotic fluid; ; visceral pleura; ; left uterine tube; ; buccal mucosa cell; ; palpebral conjunctiva;
	Top expressed in
	granulocyte; ; embryo; ; blood; ; bone marrow; ; thymus; ; yolk sac; ; spleen; ; proximal tubule; ; jejunum; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding; tumor necrosis factor receptor binding; cytokine activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein binding; identical protein binding;
Cellular component	extracellular region; cytoplasm; integral component of membrane; membrane; plasma membrane; extracellular space;
Biological process	T cell costimulation; T cell proliferation; T cell homeostasis; positive regulation of T cell chemotaxis; apoptotic process; tumor necrosis factor-mediated signaling pathway; positive regulation of myoblast fusion; T cell activation; positive regulation of myoblast differentiation; cellular response to mechanical stimulus; immune response; signal transduction; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of signaling receptor activity; positive regulation of NIK/NF-kappaB signaling;
	Sources:Amigo / QuickGO
Orthologs
	8740
	50930
	ENSG00000125735
	ENSMUSG00000005824
	O43557
	Q9QYH9
	NM_003807; NM_172014; NM_001376887
	NM_019418
	NP_003798; NP_742011; NP_001363816
	NP_062291
	Wikidata
View/Edit Human	View/Edit Mouse

LIGHT, also known as tumor necrosis factor superfamily member 14 (TNFSF14), is a secreted protein of the TNF superfamily.^[5]^[6]^[7] It is recognized by herpesvirus entry mediator (HVEM), as well as decoy receptor 3.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125735 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005824 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mauri DN, Ebner R, Montgomery RI, Kochel KD, Cheung TC, Yu GL, Ruben S, Murphy M, Eisenberg RJ, Cohen GH, Spear PG, Ware CF (January 1998). "LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator". Immunity. 8 (1): 21–30. doi:10.1016/S1074-7613(00)80455-0. PMID 9462508.
^ "Entrez Gene: TNFSF14 tumor necrosis factor (ligand) superfamily, member 14".
^ Ware C (2008). "Chapter 25: TNF-Related Cytokines in Immunity". In Paul W (ed.). Fundamental Immunology (Book) (6th ed.). Philadelphia: Lippincott Williams & Wilkins. pp. 776–801. ISBN 978-0-7817-6519-0.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125735 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005824 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9462508-5] Mauri DN, Ebner R, Montgomery RI, Kochel KD, Cheung TC, Yu GL, Ruben S, Murphy M, Eisenberg RJ, Cohen GH, Spear PG, Ware CF (January 1998). "LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator". Immunity. 8 (1): 21–30. doi:10.1016/S1074-7613(00)80455-0. PMID 9462508.

[entrez-6] "Entrez Gene: TNFSF14 tumor necrosis factor (ligand) superfamily, member 14".

[Paul2608-7] Ware C (2008). "Chapter 25: TNF-Related Cytokines in Immunity". In Paul W (ed.). Fundamental Immunology (Book) (6th ed.). Philadelphia: Lippincott Williams & Wilkins. pp. 776–801. ISBN 978-0-7817-6519-0.

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