LU domain

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1cds :28-95 1cdr :28-95 1cdq :28-95 1erg :28-95 1ywhC:25-99 1vyeA:23-80

u-PAR/Ly-6 domain
u-PAR/Ly-6 domain
	Crystallographic structure of non-glycosylated human CD59.
Identifiers
Symbol	UPAR_LY6
Pfam	PF00021
InterPro	IPR001526
PROSITE	PDOC00756
CATH	1erg
SCOP2	1erg / SCOPe / SUPFAM
CDD	cd00117
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1cds :28-95 1cdr :28-95 1cdq :28-95 1erg :28-95 1ywhC:25-99 1vyeA:23-80

The LU domain (Ly-6 antigen/uPAR) is an evolutionarily conserved protein domain of the three-finger protein superfamily. This domain is found in the extracellular domains of cell-surface receptors and in either GPI-anchored or secreted globular proteins, for example the Ly-6 family, CD59, and Sgp-2.^[2]^[3]

A variety of GPI-linked cell-surface glycoproteins are composed of one or more copies of a conserved LU domain of about 100 amino-acid residues.^[4]^[5] Among these proteins, most contain only a single LU domain, though small numbers of exceptions are known; well-studied family member uPAR has three tandem LU domains.^[3]

^ PDB: 2J8B; Leath KJ, Johnson S, Roversi P, Hughes TR, Smith RA, Mackenzie L, Morgan BP, Lea SM (August 2007). "High-resolution structures of bacterially expressed soluble human CD59". Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 63 (Pt 8): 648–52. doi:10.1107/S1744309107033477. PMC 2335151. PMID 17671359.
^ Kessler P, Marchot P, Silva M, Servent D (August 2017). "The three-finger toxin fold: a multifunctional structural scaffold able to modulate cholinergic functions". Journal of Neurochemistry. 142 (Suppl 2): 7–18. doi:10.1111/jnc.13975. PMID 28326549.
^ ^a ^b Loughner CL, Bruford EA, McAndrews MS, Delp EE, Swamynathan S, Swamynathan SK (April 2016). "Organization, evolution and functions of the human and mouse Ly6/uPAR family genes". Human Genomics. 10: 10. doi:10.1186/s40246-016-0074-2. PMC 4839075. PMID 27098205.
^ Behrendt N, Ploug M, Patthy L, Houen G, Blasi F, Danø K (April 1991). "The ligand-binding domain of the cell surface receptor for urokinase-type plasminogen activator". The Journal of Biological Chemistry. 266 (12): 7842–7. doi:10.1016/S0021-9258(20)89526-X. PMID 1850423.
^ Ploug M, Kjalke M, Rønne E, Weidle U, Høyer-Hansen G, Danø K (August 1993). "Localization of the disulfide bonds in the NH2-terminal domain of the cellular receptor for human urokinase-type plasminogen activator. A domain structure belonging to a novel superfamily of glycolipid-anchored membrane proteins". The Journal of Biological Chemistry. 268 (23): 17539–46. doi:10.1016/S0021-9258(19)85366-8. PMID 8394346.

[pmid17671359-1] PDB: 2J8B; Leath KJ, Johnson S, Roversi P, Hughes TR, Smith RA, Mackenzie L, Morgan BP, Lea SM (August 2007). "High-resolution structures of bacterially expressed soluble human CD59". Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 63 (Pt 8): 648–52. doi:10.1107/S1744309107033477. PMC 2335151. PMID 17671359.

[kessler_2017-2] Kessler P, Marchot P, Silva M, Servent D (August 2017). "The three-finger toxin fold: a multifunctional structural scaffold able to modulate cholinergic functions". Journal of Neurochemistry. 142 (Suppl 2): 7–18. doi:10.1111/jnc.13975. PMID 28326549.

[loughner_2016-3] Loughner CL, Bruford EA, McAndrews MS, Delp EE, Swamynathan S, Swamynathan SK (April 2016). "Organization, evolution and functions of the human and mouse Ly6/uPAR family genes". Human Genomics. 10: 10. doi:10.1186/s40246-016-0074-2. PMC 4839075. PMID 27098205.

[PUB00002692-4] Behrendt N, Ploug M, Patthy L, Houen G, Blasi F, Danø K (April 1991). "The ligand-binding domain of the cell surface receptor for urokinase-type plasminogen activator". The Journal of Biological Chemistry. 266 (12): 7842–7. doi:10.1016/S0021-9258(20)89526-X. PMID 1850423.

[PUB00002796-5] Ploug M, Kjalke M, Rønne E, Weidle U, Høyer-Hansen G, Danø K (August 1993). "Localization of the disulfide bonds in the NH2-terminal domain of the cellular receptor for human urokinase-type plasminogen activator. A domain structure belonging to a novel superfamily of glycolipid-anchored membrane proteins". The Journal of Biological Chemistry. 268 (23): 17539–46. doi:10.1016/S0021-9258(19)85366-8. PMID 8394346.

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