Lamotrigine, sold under the brand name Lamictal among others, is a medication used to treat epilepsy and stabilize mood in bipolar disorder.[5][8] For epilepsy, this includes focal seizures, tonic-clonic seizures, and seizures in Lennox-Gastaut syndrome.[8] In bipolar disorder, lamotrigine has not been shown to reliably treat acute depression for all groups except in the severely depressed; but for patients with bipolar disorder who are not currently symptomatic, it appears to reduce the risk of future episodes of depression.[9]
Lamotrigine was first marketed in Ireland in 1991,[12] and approved for use in the United States in 1994.[8][13] It is on the World Health Organization's List of Essential Medicines.[14] In 2021, it was the 50th most commonly prescribed medication in the United States, with more than 13million prescriptions.[15][16]
^Cite error: The named reference brands was invoked but never defined (see the help page).
^"Lamotrigine". PubChem Open Chemistry Database. US: National Institutes of Health. Archived from the original on 6 September 2016. Retrieved 13 December 2016.
^Cite error: The named reference pmid 18001843 was invoked but never defined (see the help page).
^Shorvon SD, Perucca E, Engel J (2015). The Treatment of Epilepsy (4th ed.). John Wiley & Sons, Incorporated. p. 1321. ISBN9781118936993. Archived from the original on 2 August 2021. Retrieved 31 August 2020.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.