The causes of LOCAH are the same as of classic CAH, and in the majority of the cases are the mutations in the CYP21A2 gene resulting in corresponding activity changes in the associated P450c21 (21-hydroxylase)enzyme which ultimately leads to excessive androgen production. Other causes, albeit less frequent, are mutations in genes affecting other enzymes involved in steroidmetabolism, like 11β-hydroxylase or 3β-hydroxysteroid dehydrogenase.[3] It has a prevalence between 0.1% and 2% depending on population,[2] and is one of the most common autosomal recessive genetic diseases in humans.[5][6][7] The pathophysiology is complex and not all individuals are symptomatic.[2]
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