Leptin receptor

LEPR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3V6O
Identifiers
Aliases	LEPR, CD295, LEP-R, LEPRD, OB-R, OBR, leptin receptor
External IDs	OMIM: 601007; MGI: 104993; HomoloGene: 1731; GeneCards: LEPR; OMA:LEPR - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.3 Start 65,420,652 bp[1] End 65,641,559 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 C6|4 46.96 cM Start 101,574,601 bp[2] End 101,672,549 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trabecular bone Epithelium of choroid plexus trigeminal ganglion pericardium skin of hip oral cavity mucosa of pharynx lower lobe of lung skin of thigh urethra Top expressed in lumbar spinal ganglion Epithelium of choroid plexus dermis right lung mesenteric lymph nodes aortic valve membranous bone Dermatocranium right lung lobe Paneth cell More reference expression data BioGPS n/a
Gene ontology Molecular function leptin receptor activity protein binding identical protein binding cytokine receptor activity transmembrane signaling receptor activity peptide hormone binding cytokine binding Cellular component integral component of membrane membrane receptor complex plasma membrane extracellular region basolateral plasma membrane external side of plasma membrane Biological process sexual reproduction glucose homeostasis leptin-mediated signaling pathway cholesterol metabolic process negative regulation of hydrolase activity regulation of feeding behavior multicellular organism development negative regulation of gluconeogenesis cell surface receptor signaling pathway T cell differentiation angiogenesis energy homeostasis bone growth energy reserve metabolic process response to leptin negative regulation of autophagy regulation of bone remodeling phagocytosis positive regulation of cold-induced thermogenesis glycogen metabolic process glial cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3953 16847 Ensembl ENSG00000116678 ENSMUSG00000057722 UniProt P48357 P48356 RefSeq (mRNA) NM_002303 NM_001003679 NM_001003680 NM_001198687 NM_001198688 NM_001198689 NM_001122899 NM_010704 NM_146146 RefSeq (protein) NP_001003679 NP_001003680 NP_001185616 NP_001185617 NP_001185618 NP_002294 NP_001116371 NP_034834 NP_666258 Location (UCSC) Chr 1: 65.42 – 65.64 Mb Chr 4: 101.57 – 101.67 Mb PubMed search [3] [4]
Wikidata
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Leptin receptor, also known as LEP-R or OB-R, is a type I cytokine receptor,^[5] a protein that in humans is encoded by the LEPR gene.^[6][7] LEP-R functions as a receptor for the fat cell-specific hormone leptin. LEP-R has also been designated as CD295 (cluster of differentiation 295). Its location is the cell membrane, and it has extracellular, trans-membrane and intracellular sections (protein regions).