Levobunolol

Levobunolol
Clinical data
Trade names	AKBeta, Betagan, Vistagan, others
AHFS/Drugs.com	Monograph
MedlinePlus	a686011
Pregnancy; category	C;
Routes of; administration	Topical eye drop
ATC code	S01ED03 (WHO) ;
Legal status
Legal status	US: ℞-only; EU: Rx-only;
Pharmacokinetic data
Bioavailability	7.5% (rabbit eye)
Metabolites	dihydrolevobunolol (equally active)
Onset of action	≤ 1 hour
Elimination half-life	6 hours
Duration of action	up to 16 hours
Excretion	mostly renal
Identifiers
	IUPAC name (S)-5-{[3-(tert-Butylamino)-2-hydroxypropyl]oxy}-3,4-dihydronaphthalen-1(2H)-one;
CAS Number	47141-42-4 ;
PubChem CID	39468;
IUPHAR/BPS	570;
DrugBank	DB01210 ;
ChemSpider	36089 ;
UNII	G6317AOI7K;
KEGG	D08115 ;
ChEBI	CHEBI:6438 ;
ChEMBL	ChEMBL1201237 ;
CompTox Dashboard (EPA)	DTXSID1043833 ;
Chemical and physical data
Formula	C17H25NO3
Molar mass	291.391 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	209 to 211 °C (408 to 412 °F) (hydrochloride)
Solubility in water	soluble (hydrochloride)
	SMILES O=C2c1cccc(OC[C@@H](O)CNC(C)(C)C)c1CCC2;
	InChI InChI=1S/C17H25NO3/c1-17(2,3)18-10-12(19)11-21-16-9-5-6-13-14(16)7-4-8-15(13)20/h5-6,9,12,18-19H,4,7-8,10-11H2,1-3H3/t12-/m0/s1 ; Key:IXHBTMCLRNMKHZ-LBPRGKRZSA-N ;
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Levobunolol (trade names AKBeta, Betagan, Vistagan, among others) is a non-selective beta blocker. It is used topically in the form of eye drops to manage ocular hypertension (high pressure in the eye) and open-angle glaucoma.^[3]

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^ Cite error: The named reference Arzneistoff-Profile was invoked but never defined (see the help page).
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[1] "Archived copy" (PDF). Archived (PDF) from the original on 2022-09-06. Retrieved 2022-09-06.{{cite web}}: CS1 maint: archived copy as title (link)

[Arzneistoff-Profile-2] Cite error: The named reference Arzneistoff-Profile was invoked but never defined (see the help page).

[AustriaCodex-3] Cite error: The named reference AustriaCodex was invoked but never defined (see the help page).

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