Low-affinity nerve growth factor receptor

NGFR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3EWV, 2N80, 2N97, 2N83
Identifiers
Aliases	NGFR, CD271, Gp80-LTNFRSF16, p75(NTR), p75NTR, nerve growth factor receptor
External IDs	OMIM: 162010; MGI: 97323; HomoloGene: 1877; GeneCards: NGFR; OMA:NGFR - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	49,515,008 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	95,478,561 bp
RNA expression pattern
	Top expressed in
	tibial nerve; ; spinal ganglia; ; apex of heart; ; sural nerve; ; right auricle; ; right lobe of thyroid gland; ; testicle; ; trigeminal ganglion; ; left uterine tube; ; left lobe of thyroid gland;
	Top expressed in
	spinal ganglia; ; lumbar spinal ganglion; ; submandibular gland; ; external carotid artery; ; cervix; ; Gonadal ridge; ; internal carotid artery; ; trigeminal ganglion; ; tunica adventitia of aorta; ; maxillary prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; transmembrane signaling receptor activity; tumor necrosis factor-activated receptor activity; ubiquitin protein ligase binding; protein binding; calmodulin binding; coreceptor activity; neurotrophin binding; nerve growth factor binding; amyloid-beta binding; death receptor activity; signaling receptor activity;
Cellular component	extracellular region; nucleoplasm; integral component of membrane; cytosol; integral component of plasma membrane; neuron projection; membrane; cell surface; endosome; nucleus; plasma membrane;
Biological process	rhythmic process; regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process; neurotrophin TRK receptor signaling pathway; signal transduction; axon guidance; multicellular organism development; apoptotic process; negative regulation of axonogenesis; nervous system development; glucose homeostasis; positive regulation of axonogenesis; circadian regulation of gene expression; membrane protein intracellular domain proteolysis; cell differentiation; inflammatory response; immune response; intracellular protein transport; positive regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; tumor necrosis factor-mediated signaling pathway; response to lipopolysaccharide; apoptotic signaling pathway; negative regulation of neuron projection development; activation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of protein localization to nucleus; positive regulation of pri-miRNA transcription by RNA polymerase II; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; Rho protein signal transduction; cellular glucose homeostasis; neuron apoptotic process; cellular response to amyloid-beta;
	Sources:Amigo / QuickGO
Orthologs
	4804
	18053
	ENSG00000064300
	ENSMUSG00000000120
	P08138
	Q9Z0W1
	NM_002507
	NM_033217
	NP_002498
	NP_150086
	Wikidata
View/Edit Human	View/Edit Mouse

The p75 neurotrophin receptor (p75NTR) was first identified in 1973 as the low-affinity nerve growth factor receptor (LNGFR)^[5]^[6] before discovery that p75NTR bound other neurotrophins equally well as nerve growth factor.^[7]^[8] p75NTR is a neurotrophic factor receptor. Neurotrophic factor receptors bind Neurotrophins including Nerve growth factor, Neurotrophin-3, Brain-derived neurotrophic factor, and Neurotrophin-4. All neurotrophins bind to p75NTR. This also includes the immature pro-neurotrophin forms.^[9]^[10] Neurotrophic factor receptors, including p75NTR, are responsible for ensuring a proper density to target ratio of developing neurons, refining broader maps in development into precise connections. p75NTR is involved in pathways that promote neuronal survival and neuronal death.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000064300 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000120 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Johnson D, Lanahan A, Buck CR, Sehgal A, Morgan C, Mercer E, et al. (November 1986). "Expression and structure of the human NGF receptor". Cell. 47 (4): 545–554. doi:10.1016/0092-8674(86)90619-7. PMID 3022937. S2CID 22472119.
^ Radeke MJ, Misko TP, Hsu C, Herzenberg LA, Shooter EM (1987). "Gene transfer and molecular cloning of the rat nerve growth factor receptor". Nature. 325 (6105): 593–597. Bibcode:1987Natur.325..593R. doi:10.1038/325593a0. PMID 3027580. S2CID 4342838.
^ ^a ^b Bibel M, Hoppe E, Barde YA (February 1999). "Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR". The EMBO Journal. 18 (3): 616–622. doi:10.1093/emboj/18.3.616. PMC 1171154. PMID 9927421.
^ Frade JM, Barde YA (February 1998). "Nerve growth factor: two receptors, multiple functions". BioEssays. 20 (2): 137–145. doi:10.1002/(SICI)1521-1878(199802)20:2<137::AID-BIES6>3.0.CO;2-Q. PMID 9631659. S2CID 38060583.
^ Barker PA (May 2004). "p75NTR is positively promiscuous: novel partners and new insights". Neuron. 42 (4): 529–533. doi:10.1016/j.neuron.2004.04.001. PMID 15157416. S2CID 15080734.
^ Chao MV, Bothwell M (January 2002). "Neurotrophins: to cleave or not to cleave". Neuron. 33 (1): 9–12. doi:10.1016/s0896-6273(01)00573-6. PMID 11779474. S2CID 17364992.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000064300 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000120 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3022937-5] Johnson D, Lanahan A, Buck CR, Sehgal A, Morgan C, Mercer E, et al. (November 1986). "Expression and structure of the human NGF receptor". Cell. 47 (4): 545–554. doi:10.1016/0092-8674(86)90619-7. PMID 3022937. S2CID 22472119.

[pmid3027580-6] Radeke MJ, Misko TP, Hsu C, Herzenberg LA, Shooter EM (1987). "Gene transfer and molecular cloning of the rat nerve growth factor receptor". Nature. 325 (6105): 593–597. Bibcode:1987Natur.325..593R. doi:10.1038/325593a0. PMID 3027580. S2CID 4342838.

[pmid9927421-7] Bibel M, Hoppe E, Barde YA (February 1999). "Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR". The EMBO Journal. 18 (3): 616–622. doi:10.1093/emboj/18.3.616. PMC 1171154. PMID 9927421.

[8] Frade JM, Barde YA (February 1998). "Nerve growth factor: two receptors, multiple functions". BioEssays. 20 (2): 137–145. doi:10.1002/(SICI)1521-1878(199802)20:2<137::AID-BIES6>3.0.CO;2-Q. PMID 9631659. S2CID 38060583.

[9] Barker PA (May 2004). "p75NTR is positively promiscuous: novel partners and new insights". Neuron. 42 (4): 529–533. doi:10.1016/j.neuron.2004.04.001. PMID 15157416. S2CID 15080734.

[10] Chao MV, Bothwell M (January 2002). "Neurotrophins: to cleave or not to cleave". Neuron. 33 (1): 9–12. doi:10.1016/s0896-6273(01)00573-6. PMID 11779474. S2CID 17364992.

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