Lymphocyte function-associated antigen 1

Lymphocyte function-associated antigen 1 (LFA-1) is an integrin found on lymphocytes and other leukocytes.^[1] LFA-1 plays a key role in emigration, which is the process by which leukocytes leave the bloodstream to enter the tissues. LFA-1 also mediates firm arrest of leukocytes.^[2] Additionally, LFA-1 is involved in the process of cytotoxic T cell mediated killing as well as antibody mediated killing by granulocytes and monocytes.^[3] As of 2007, LFA-1 has 6 known ligands: ICAM-1, ICAM-2, ICAM-3, ICAM-4, ICAM-5, and JAM-A.^[2] LFA-1/ICAM-1 interactions have recently been shown to stimulate signaling pathways that influence T cell differentiation.^[4] LFA-1 belongs to the integrin superfamily of adhesion molecules.^[1]

^ ^a ^b Lackie JM (2010). A dictionary of biomedicine (1st ed.). Oxford: Oxford University Press. ISBN 9780191727948. OCLC 663104793.
^ ^a ^b Ley K (2007). Adhesion molecules : function and inhibition. Basel: Birkhauser. ISBN 9783764379759. OCLC 261225084.
^ Cammack R (2006). Oxford dictionary of biochemistry and molecular biology (Rev. ed.). Oxford: Oxford University Press. ISBN 9780191727641. OCLC 743217704.
^ Verma NK, Kelleher D (August 2017). "Not Just an Adhesion Molecule: LFA-1 Contact Tunes the T Lymphocyte Program". Journal of Immunology. 199 (4): 1213–1221. doi:10.4049/jimmunol.1700495. PMID 28784685.

[:0-1] Lackie JM (2010). A dictionary of biomedicine (1st ed.). Oxford: Oxford University Press. ISBN 9780191727948. OCLC 663104793.

[:1-2] Ley K (2007). Adhesion molecules : function and inhibition. Basel: Birkhauser. ISBN 9783764379759. OCLC 261225084.

[:2-3] Cammack R (2006). Oxford dictionary of biochemistry and molecular biology (Rev. ed.). Oxford: Oxford University Press. ISBN 9780191727641. OCLC 743217704.

[4] Verma NK, Kelleher D (August 2017). "Not Just an Adhesion Molecule: LFA-1 Contact Tunes the T Lymphocyte Program". Journal of Immunology. 199 (4): 1213–1221. doi:10.4049/jimmunol.1700495. PMID 28784685.

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