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MADS-box

The MADS box is a conserved sequence motif. The genes which contain this motif are called the MADS-box gene family.[1] The MADS box encodes the DNA-binding MADS domain. The MADS domain binds to DNA sequences of high similarity to the motif CC[A/T]6GG termed the CArG-box.[2] MADS-domain proteins are generally transcription factors.[2][3] The length of the MADS-box reported by various researchers varies somewhat, but typical lengths are in the range of 168 to 180 base pairs, i.e. the encoded MADS domain has a length of 56 to 60 amino acids.[4][5][6][7] There is evidence that the MADS domain evolved from a sequence stretch of a type II topoisomerase in a common ancestor of all extant eukaryotes.[8]

  1. ^ Schwarz-Sommer Z, Huijser P, Nacken W, Saedler H, Sommer H (November 1990). "Genetic Control of Flower Development by Homeotic Genes in Antirrhinum majus". Science. 250 (4983): 931–6. Bibcode:1990Sci...250..931S. doi:10.1126/science.250.4983.931. PMID 17746916. S2CID 15848590.
  2. ^ a b West AG, Shore P, Sharrocks AD (May 1997). "DNA binding by MADS-box transcription factors: a molecular mechanism for differential DNA bending". Molecular and Cellular Biology. 17 (5): 2876–87. doi:10.1128/MCB.17.5.2876. PMC 232140. PMID 9111360.
  3. ^ Svensson M (2000). Evolution of a family of plant genes with regulatory functions in development; studies on Picea abies and Lycopodium annotinum (PDF). Doctoral thesis. Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Biology, Department of Evolutionary Biology. ISBN 978-91-554-4826-4. Retrieved 2007-07-30.
  4. ^ Ma K, Chan JK, Zhu G, Wu Z (May 2005). "Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation". Molecular and Cellular Biology. 25 (9): 3575–82. doi:10.1128/MCB.25.9.3575-3582.2005. PMC 1084296. PMID 15831463.
  5. ^ Lamb RS, Irish VF (May 2003). "Functional divergence within the APETALA3/PISTILLATA floral homeotic gene lineages". Proceedings of the National Academy of Sciences of the United States of America. 100 (11): 6558–63. Bibcode:2003PNAS..100.6558L. doi:10.1073/pnas.0631708100. PMC 164485. PMID 12746493.
  6. ^ Nam J, dePamphilis CW, Ma H, Nei M (September 2003). "Antiquity and evolution of the MADS-box gene family controlling flower development in plants". Molecular Biology and Evolution. 20 (9): 1435–47. doi:10.1093/molbev/msg152. PMID 12777513.
  7. ^ Lü S, Du X, Lu W, Chong K, Meng Z (2007). "Two AGAMOUS-like MADS-box genes from Taihangia rupestris (Rosaceae) reveal independent trajectories in the evolution of class C and class D floral homeotic functions". Evolution & Development. 9 (1): 92–104. doi:10.1111/j.1525-142X.2006.00140.x. PMID 17227369. S2CID 9253584.
  8. ^ Gramzow L, Ritz MS, Theissen G (April 2010). "On the origin of MADS-domain transcription factors". Trends in Genetics. 26 (4): 149–53. doi:10.1016/j.tig.2010.01.004. PMID 20219261.

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