MSR1

MSR1
Identifiers
Aliases	MSR1, CD204, SCARA1, SR-A, SRA, phSR1, phSR2, macrophage scavenger receptor 1, SR-AI, SR-AII, SR-AIII
External IDs	OMIM: 153622; MGI: 98257; HomoloGene: 12822; GeneCards: MSR1; OMA:MSR1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	16,567,490 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	40,095,714 bp
RNA expression pattern
	Top expressed in
	right lung; ; upper lobe of left lung; ; gallbladder; ; Achilles tendon; ; right coronary artery; ; visceral pleura; ; Descending thoracic aorta; ; monocyte; ; testicle; ; ascending aorta;
	Top expressed in
	stroma of bone marrow; ; spermatid; ; molar; ; mesenteric lymph nodes; ; gastrula; ; liver; ; seminiferous tubule; ; left lobe of liver; ; submandibular gland; ; sciatic nerve;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	scavenger receptor activity; protein binding; low-density lipoprotein particle binding; amyloid-beta binding; cargo receptor activity;
Cellular component	integral component of membrane; endocytic vesicle membrane; cytosol; plasma membrane; collagen; integral component of plasma membrane; membrane; low-density lipoprotein particle; cytoplasmic vesicle;
Biological process	cholesterol transport; plasma lipoprotein particle clearance; cellular response to organic cyclic compound; positive regulation of macrophage derived foam cell differentiation; endocytosis; receptor-mediated endocytosis; lipoprotein transport; positive regulation of cholesterol storage; phagocytosis, engulfment; negative regulation of gene expression; amyloid-beta clearance;
	Sources:Amigo / QuickGO
Orthologs
	4481
	20288
	ENSG00000038945
	ENSMUSG00000025044
	P21757
	P30204
	NM_138716; NM_002445; NM_138715; NM_001363744
	NM_001113326; NM_031195
	NP_002436; NP_619729; NP_619730; NP_001350673
	NP_001106797; NP_112472
	Wikidata
View/Edit Human	View/Edit Mouse

Macrophage scavenger receptor 1, also known as MSR1, is a protein which in humans is encoded by the MSR1 gene.^[5]^[6] MSR1 has also been designated CD204 (cluster of differentiation 204).

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000038945 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025044 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MSR1 macrophage scavenger receptor 1".
^ Matsumoto A, Naito M, Itakura H, Ikemoto S, Asaoka H, Hayakawa I, Kanamori H, Aburatani H, Takaku F, Suzuki H (December 1990). "Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions". Proc. Natl. Acad. Sci. U.S.A. 87 (23): 9133–7. Bibcode:1990PNAS...87.9133M. doi:10.1073/pnas.87.23.9133. PMC 55118. PMID 2251254.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000038945 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025044 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MSR1 macrophage scavenger receptor 1".

[pmid2251254-6] Matsumoto A, Naito M, Itakura H, Ikemoto S, Asaoka H, Hayakawa I, Kanamori H, Aburatani H, Takaku F, Suzuki H (December 1990). "Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions". Proc. Natl. Acad. Sci. U.S.A. 87 (23): 9133–7. Bibcode:1990PNAS...87.9133M. doi:10.1073/pnas.87.23.9133. PMC 55118. PMID 2251254.

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