Macrophage colony-stimulating factor

CSF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HMC, 3UEZ, 3UF2, 4ADF, 4FA8, 4WRL, 4WRM
Identifiers
Aliases	CSF1, CSF-1, MCSF, colony stimulating factor 1
External IDs	OMIM: 120420; MGI: 1339753; HomoloGene: 7282; GeneCards: CSF1; OMA:CSF1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.3 Start 109,910,242 bp[1] End 109,930,992 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F2.3|3 46.83 cM Start 107,648,364 bp[2] End 107,667,785 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gallbladder subcutaneous adipose tissue right coronary artery apex of heart left adrenal gland left coronary artery cartilage tissue right adrenal gland right adrenal cortex left adrenal cortex Top expressed in stroma of bone marrow aortic valve ascending aorta mesenteric lymph nodes calvaria endothelial cell of lymphatic vessel ankle joint zygote secondary oocyte supraoptic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding macrophage colony-stimulating factor receptor binding protein homodimerization activity growth factor activity cytokine activity identical protein binding Cellular component integral component of membrane perinuclear region of cytoplasm CSF1-CSF1R complex membrane extracellular space endoplasmic reticulum lumen extracellular region plasma membrane Biological process positive regulation of microglial cell migration cell differentiation positive regulation of protein metabolic process mammary gland fat development branching involved in mammary gland duct morphogenesis transmembrane receptor protein tyrosine kinase signaling pathway immune system process positive regulation of Ras protein signal transduction positive regulation of macrophage colony-stimulating factor signaling pathway mammary duct terminal end bud growth monocyte activation positive regulation of macrophage derived foam cell differentiation positive regulation of gene expression macrophage colony-stimulating factor signaling pathway positive regulation of odontogenesis of dentin-containing tooth positive regulation of cell population proliferation regulation of macrophage derived foam cell differentiation positive regulation of multicellular organism growth homeostasis of number of cells within a tissue regulation of ossification inflammatory response positive regulation of macrophage chemotaxis innate immune response positive regulation of mononuclear cell proliferation osteoclast proliferation positive regulation of osteoclast differentiation positive regulation of cell migration positive regulation of monocyte differentiation positive regulation of protein kinase activity developmental process involved in reproduction positive regulation of cell-matrix adhesion positive regulation of macrophage differentiation cell population proliferation macrophage differentiation post-translational protein modification regulation of signaling receptor activity cytokine-mediated signaling pathway hemopoiesis osteoclast differentiation response to ischemia microglial cell proliferation negative regulation of neuron death Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1435 12977 Ensembl ENSG00000184371 ENSMUSG00000014599 UniProt P09603 P07141 RefSeq (mRNA) NM_172212 NM_000757 NM_172210 NM_172211 NM_001113529 NM_001113530 NM_007778 RefSeq (protein) NP_000748 NP_757349 NP_757350 NP_757351 NP_001107001 NP_001107002 NP_031804 Location (UCSC) Chr 1: 109.91 – 109.93 Mb Chr 3: 107.65 – 107.67 Mb PubMed search [3] [4]
Wikidata
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The colony stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a secreted cytokine which causes hematopoietic stem cells to differentiate into macrophages or other related cell types. Eukaryotic cells also produce M-CSF in order to combat intercellular viral infection. It is one of the three experimentally described colony-stimulating factors. M-CSF binds to the colony stimulating factor 1 receptor. It may also be involved in development of the placenta.^[5]