Macrophage inflammatory protein

chemokine (C-C motif) ligand 4
chemokine (C-C motif) ligand 4
	Human Mip-1β dimer. PDB 1hum. Disulfide bonds highlighted.
Identifiers
Symbol	CCL4
Alt. symbols	SCYA4, MIP-1β, LAG1
NCBI gene	6351
HGNC	10630
OMIM	182284
PDB	1HUM More structures
RefSeq	NM_002984
UniProt	P13236
Other data
Locus	Chr. 17 q21-q23
Structures
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Structures	Swiss-model
Domains	InterPro

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Structures	Swiss-model
Domains	InterPro

chemokine (C-C motif) ligand 3
chemokine (C-C motif) ligand 3
	Human Mip-1α dimer D26A mutant. PDB 1b53. Disulfide bonds highlighted.
Identifiers
Symbol	CCL3
Alt. symbols	SCYA3, MIP-1α
NCBI gene	6348
HGNC	10627
OMIM	182283
PDB	1B50 More structures
RefSeq	NM_002983
UniProt	P10147
Other data
Locus	Chr. 17 q12
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Macrophage Inflammatory Proteins (MIP) belong to the family of chemotactic cytokines known as chemokines. In humans, there are two major forms, MIP-1α and MIP-1β, renamed CCL3 and CCL4 respectively, since 2000.^[3] However, other names are sometimes encountered in older literature, such as LD78α, AT 464.1 and GOS19-1 for human CCL3 and AT 744, Act-2, LAG-1, HC21 and G-26 for human CCL4.^[4] Other macrophage inflammatory proteins include MIP-2, MIP-3 and MIP-5.

^ Czaplewski LG, McKeating J, Craven CJ, Higgins LD, Appay V, Brown A, et al. (June 1999). "Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants". The Journal of Biological Chemistry. 274 (23): 16077–84. doi:10.1074/jbc.274.23.16077. PMID 10347159.
^ Lodi PJ, Garrett DS, Kuszewski J, Tsang ML, Weatherbee JA, Leonard WJ, et al. (March 1994). "High-resolution solution structure of the beta chemokine hMIP-1 beta by multidimensional NMR". Science. 263 (5154): 1762–7. Bibcode:1994Sci...263.1762L. doi:10.1126/science.8134838. PMID 8134838.
^ Zlotnik A, Yoshie O (February 2000). "Chemokines: a new classification system and their role in immunity". Immunity. 12 (2): 121–7. doi:10.1016/S1074-7613(00)80165-X. PMID 10714678.
^ Menten P, Wuyts A, Van Damme J (December 2002). "Macrophage inflammatory protein-1". Cytokine & Growth Factor Reviews. 13 (6): 455–81. doi:10.1016/S1359-6101(02)00045-X. PMID 12401480.

[1] Czaplewski LG, McKeating J, Craven CJ, Higgins LD, Appay V, Brown A, et al. (June 1999). "Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants". The Journal of Biological Chemistry. 274 (23): 16077–84. doi:10.1074/jbc.274.23.16077. PMID 10347159.

[2] Lodi PJ, Garrett DS, Kuszewski J, Tsang ML, Weatherbee JA, Leonard WJ, et al. (March 1994). "High-resolution solution structure of the beta chemokine hMIP-1 beta by multidimensional NMR". Science. 263 (5154): 1762–7. Bibcode:1994Sci...263.1762L. doi:10.1126/science.8134838. PMID 8134838.

[:0-3] Zlotnik A, Yoshie O (February 2000). "Chemokines: a new classification system and their role in immunity". Immunity. 12 (2): 121–7. doi:10.1016/S1074-7613(00)80165-X. PMID 10714678.

[Menten_2002-4] Menten P, Wuyts A, Van Damme J (December 2002). "Macrophage inflammatory protein-1". Cytokine & Growth Factor Reviews. 13 (6): 455–81. doi:10.1016/S1359-6101(02)00045-X. PMID 12401480.

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