Mannose receptor

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Structures	Swiss-model
Domains	InterPro

mannose receptor, C type 1
mannose receptor, C type 1
Identifiers
Symbol	MRC1
Alt. symbols	CD206
NCBI gene	4360
HGNC	7228
OMIM	153618
RefSeq	NM_002438
UniProt	P22897
Other data
Locus	Chr. 10 p13
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Macrophage mannose receptor
Macrophage mannose receptor
Identifiers
Symbol	MMR
Membranome	56

mannose receptor, C type 2

Identifiers

Symbol

MRC2

Alt. symbols

CD280

Other data

Chr. 17 q23

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Structures	Swiss-model
Domains	InterPro

The mannose receptor (Cluster of Differentiation 206, CD206) is a C-type lectin primarily present on the surface of macrophages, immature dendritic cells and liver sinusoidal endothelial cells, but is also expressed on the surface of skin cells such as human dermal fibroblasts and keratinocytes.^[1]^[2] It is the first member of a family of endocytic receptors that includes Endo180 (CD280), M-type PLA2R, and DEC-205 (CD205).^[3]

The receptor recognises terminal mannose, N-acetylglucosamine and fucose residues on glycans attached to proteins ^[4] found on the surface of some microorganisms, playing a role in both the innate and adaptive immune systems. Additional functions include clearance of glycoproteins from circulation, including sulphated glycoprotein hormones and glycoproteins released in response to pathological events.^[5] The mannose receptor recycles continuously between the plasma membrane and endosomal compartments in a clathrin-dependent manner.^[6]

^ Szolnoky G, Bata-Csörgö Z, Kenderessy AS, Kiss M, Pivarcsi A, Novák Z, Nagy Newman K, Michel G, Ruzicka T, Maródi L, Dobozy A, Kemény L (August 2001). "A mannose-binding receptor is expressed on human keratinocytes and mediates killing of Candida albicans". Journal of Investigative Dermatology. 117 (2): 205–13. doi:10.1046/j.1523-1747.2001.14071.x. PMID 11511295.
^ Sheikh H, Yarwood H, Ashworth A, Isacke CM (March 2000). "Endo180, an endocytic recycling glycoprotein related to the macrophage mannose receptor is expressed on fibroblasts, endothelial cells and macrophages and functions as a lectin receptor". Journal of Cell Science. 113 (6): 1021–32. doi:10.1242/jcs.113.6.1021. PMID 10683150.
^ East L, Isacke CM (2002). "The mannose receptor family". Biochimica et Biophysica Acta (BBA) - General Subjects. 1572 (2–3): 364–86. doi:10.1016/S0304-4165(02)00319-7. PMID 12223280.
^ Schlesinger PH, Doebber TW, Mandell BF, White R, DeSchryver C, Rodman JS, Miller MJ, Stahl P (1978). "Plasma clearance of glycoproteins with terminal mannose and N-acetylglucosamine by liver non-parenchymal cells. Studies with beta-glucuronidase, N-acetyl-β-D-glucosaminidase, ribonuclease B and agalacto-orosomucoid". Biochemical Journal. 176 (1): 103–9. doi:10.1042/bj1760103. PMC 1186209. PMID 728098.
^ Lee SJ, Evers S, Roeder D, Parlow AF, Risteli J, Risteli L, Lee YC, Feizi T, Langen H, Nussenzweig MC (2002). "Mannose receptor-mediated regulation of serum glycoprotein homeostasis". Science. 295 (5561): 1898–901. Bibcode:2002Sci...295.1898L. doi:10.1126/science.1069540. PMID 11884756. S2CID 31432874.
^ Gazi U, Martinez-Pomares L (2009). "Influence of the mannose receptor in host immune responses". Immunobiology. 214 (7): 554–61. doi:10.1016/j.imbio.2008.11.004. PMID 19162368.

[pmid11511295-1] Szolnoky G, Bata-Csörgö Z, Kenderessy AS, Kiss M, Pivarcsi A, Novák Z, Nagy Newman K, Michel G, Ruzicka T, Maródi L, Dobozy A, Kemény L (August 2001). "A mannose-binding receptor is expressed on human keratinocytes and mediates killing of Candida albicans". Journal of Investigative Dermatology. 117 (2): 205–13. doi:10.1046/j.1523-1747.2001.14071.x. PMID 11511295.

[pmid10683150-2] Sheikh H, Yarwood H, Ashworth A, Isacke CM (March 2000). "Endo180, an endocytic recycling glycoprotein related to the macrophage mannose receptor is expressed on fibroblasts, endothelial cells and macrophages and functions as a lectin receptor". Journal of Cell Science. 113 (6): 1021–32. doi:10.1242/jcs.113.6.1021. PMID 10683150.

[East2002-3] East L, Isacke CM (2002). "The mannose receptor family". Biochimica et Biophysica Acta (BBA) - General Subjects. 1572 (2–3): 364–86. doi:10.1016/S0304-4165(02)00319-7. PMID 12223280.

[Schlesinger1978-4] Schlesinger PH, Doebber TW, Mandell BF, White R, DeSchryver C, Rodman JS, Miller MJ, Stahl P (1978). "Plasma clearance of glycoproteins with terminal mannose and N-acetylglucosamine by liver non-parenchymal cells. Studies with beta-glucuronidase, N-acetyl-β-D-glucosaminidase, ribonuclease B and agalacto-orosomucoid". Biochemical Journal. 176 (1): 103–9. doi:10.1042/bj1760103. PMC 1186209. PMID 728098.

[Lee2002-5] Lee SJ, Evers S, Roeder D, Parlow AF, Risteli J, Risteli L, Lee YC, Feizi T, Langen H, Nussenzweig MC (2002). "Mannose receptor-mediated regulation of serum glycoprotein homeostasis". Science. 295 (5561): 1898–901. Bibcode:2002Sci...295.1898L. doi:10.1126/science.1069540. PMID 11884756. S2CID 31432874.

[Gazi2009-6] Gazi U, Martinez-Pomares L (2009). "Influence of the mannose receptor in host immune responses". Immunobiology. 214 (7): 554–61. doi:10.1016/j.imbio.2008.11.004. PMID 19162368.

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