Melnychuk is Ukrainian surname and a patronymic derivative of Melnyk. Alternative spellings: via Russian: Melnichuk, via Polish: Melniczuk/Melnyczuk. Notable people with the surname include:
- Alexei Melnichuk, Russian ice hockey player
- Askold Melnyczuk, American writer
- Dmytro Melnychuk (born 1943), Ukrainian scientist
- Maksym Melnychuk (born 1999), Ukrainian football player
- Valentyn Melnychuk (born 1940), Ukrainian men's basketball coach
- Vasyl Melnychuk (born 1957), Ukrainian football referee
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