Menerba

Menerba, also known as Menopause Formula 101 (MF-101), is a botanical drug candidate that acts as a selective estrogen receptor modulator (SERM)^[1] which is being studied for its potential to relieve hot flashes associated with menopause. Menerba, an estrogen receptor beta (ERβ) agonist (ERBA), is part of a new class of receptor subtype-selective estrogens,^[2] which is selective in transcriptional regulation to one of the two known estrogen receptor (ER) subtypes. Menerba consists of 22 herbs that have been used historically in traditional Chinese medicine.^[3]

Menerba binds to both ERα and ERβ and with equal affinity, but does not activate ERα and instead activates only ERβ-mediated gene transcription.^[4]^[5]

^ Grady, Deborah; Sawaya, George F.; Johnson, Karen C.; Koltun, William; Hess, Rachel; Vittinghoff, Eric; Kristof, Margaret; Tagliaferri, Mary; et al. (2009). "MF101, a selective estrogen receptor β modulator for the treatment of menopausal hot flushes". Menopause. 16 (3): 458–65. doi:10.1097/gme.0b013e31818e64dd. PMID 19182698. S2CID 31985236.
^ Paruthiyil, Sreenivasan; Cvoro, Aleksandra; Zhao, Xiaoyue; Wu, Zhijin; Sui, Yunxia; Staub, Richard E.; Baggett, Scott; Herber, Candice B.; et al. (2009). Laudet, Vincent (ed.). "Drug and Cell Type-Specific Regulation of Genes with Different Classes of Estrogen Receptor β-Selective Agonists". PLOS ONE. 4 (7): e6271. Bibcode:2009PLoSO...4.6271P. doi:10.1371/journal.pone.0006271. PMC 2707612. PMID 19609440.
^ Stovall, DW; Pinkerton, JV (2009). "MF-101, an estrogen receptor beta agonist for the treatment of vasomotor symptoms in peri- and postmenopausal women". Current Opinion in Investigational Drugs. 10 (4): 365–71. PMID 19337958.
^ Jackson, Richard L; Greiwe, Jeffrey S; Schwen, Richard J (2011). "Emerging evidence of the health benefits of S-equol, an estrogen receptor β agonist". Nutrition Reviews. 69 (8): 432–448. doi:10.1111/j.1753-4887.2011.00400.x. ISSN 0029-6643. PMID 21790611.
^ Kaunitz, Andrew M. (2009). "Effective herbal treatment of vasomotor symptoms-are we any closer?". Menopause. 16 (3): 428–429. doi:10.1097/gme.0b013e31819774e4. ISSN 1072-3714. PMID 19169160.

[pmid19182698-1] Grady, Deborah; Sawaya, George F.; Johnson, Karen C.; Koltun, William; Hess, Rachel; Vittinghoff, Eric; Kristof, Margaret; Tagliaferri, Mary; et al. (2009). "MF101, a selective estrogen receptor β modulator for the treatment of menopausal hot flushes". Menopause. 16 (3): 458–65. doi:10.1097/gme.0b013e31818e64dd. PMID 19182698. S2CID 31985236.

[pmid19609440-2] Paruthiyil, Sreenivasan; Cvoro, Aleksandra; Zhao, Xiaoyue; Wu, Zhijin; Sui, Yunxia; Staub, Richard E.; Baggett, Scott; Herber, Candice B.; et al. (2009). Laudet, Vincent (ed.). "Drug and Cell Type-Specific Regulation of Genes with Different Classes of Estrogen Receptor β-Selective Agonists". PLOS ONE. 4 (7): e6271. Bibcode:2009PLoSO...4.6271P. doi:10.1371/journal.pone.0006271. PMC 2707612. PMID 19609440.

[3] Stovall, DW; Pinkerton, JV (2009). "MF-101, an estrogen receptor beta agonist for the treatment of vasomotor symptoms in peri- and postmenopausal women". Current Opinion in Investigational Drugs. 10 (4): 365–71. PMID 19337958.

[JacksonGreiwe2011-4] Jackson, Richard L; Greiwe, Jeffrey S; Schwen, Richard J (2011). "Emerging evidence of the health benefits of S-equol, an estrogen receptor β agonist". Nutrition Reviews. 69 (8): 432–448. doi:10.1111/j.1753-4887.2011.00400.x. ISSN 0029-6643. PMID 21790611.

[Kaunitz2009-5] Kaunitz, Andrew M. (2009). "Effective herbal treatment of vasomotor symptoms-are we any closer?". Menopause. 16 (3): 428–429. doi:10.1097/gme.0b013e31819774e4. ISSN 1072-3714. PMID 19169160.

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