Mitochondrial biogenesis is the process by which cells increase mitochondrial numbers.[1][2] It was first described by John Holloszy in the 1960s, when it was discovered that physical endurance training induced higher mitochondrial content levels, leading to greater glucose uptake by muscles.[3] Mitochondrial biogenesis is activated by numerous different signals during times of cellular stress or in response to environmental stimuli, such as aerobic exercise.[1][2][4]
- ^ a b Valero T (2014). "Editorial (Thematic Issue: Mitochondrial Biogenesis: Pharmacological Approaches)". Current Pharmaceutical Design. 20 (35): 5507–5509. doi:10.2174/138161282035140911142118. hdl:10454/13341. PMID 24606795.
- ^ a b Sanchis-Gomar F, García-Giménez JL, Gómez-Cabrera MC, Pallardó FV (2014). "Mitochondrial biogenesis in health and disease. Molecular and therapeutic approaches". Current Pharmaceutical Design. 20 (35): 5619–33. doi:10.2174/1381612820666140306095106. PMID 24606801.
- ^ Holloszy JO (April 2011). "RRegulation of Mitochondrial Biogenesis and GLUT4 Expression by Exercise". Comprehensive Physiology. 1 (2): 921–40. doi:10.1002/cphy.c100052. ISBN 9780470650714. PMID 23737207.
- ^ Boushel R, Lundby C, Qvortrup K, Sahlin K (October 2014). "Mitochondrial plasticity with exercise training and extreme environments". Exercise and Sport Sciences Reviews. 42 (4): 169–74. doi:10.1249/JES.0000000000000025. PMID 25062000. S2CID 39267910.
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