Muscarinic acetylcholine receptor M1

CHRM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5CXV
Identifiers
Aliases	CHRM1, HM1, M1, M1R, cholinergic receptor muscarinic 1
External IDs	OMIM: 118510; MGI: 88396; HomoloGene: 20189; GeneCards: CHRM1; OMA:CHRM1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	62,921,807 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	8,660,951 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; middle temporal gyrus; ; Brodmann area 9; ; right frontal lobe; ; superior frontal gyrus; ; nucleus accumbens; ; postcentral gyrus; ; cingulate gyrus; ; anterior cingulate cortex; ; putamen;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; primary visual cortex; ; hippocampus proper; ; olfactory tubercle; ; nucleus accumbens; ; primary motor cortex; ; piriform cortex; ; prefrontal cortex; ; perirhinal cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; phosphatidylinositol phospholipase C activity; G protein-coupled acetylcholine receptor activity; neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential; G protein-coupled serotonin receptor activity; neurotransmitter receptor activity;
Cellular component	axon terminus; integral component of membrane; postsynaptic membrane; membrane; postsynaptic density; plasma membrane; integral component of plasma membrane; cell junction; dendrite; asymmetric synapse; synapse; Schaffer collateral - CA1 synapse; glutamatergic synapse; cholinergic synapse; integral component of postsynaptic membrane; integral component of presynaptic membrane; integral component of postsynaptic density membrane;
Biological process	positive regulation of intracellular protein transport; G protein-coupled receptor signaling pathway; cognition; regulation of locomotion; synaptic transmission, cholinergic; saliva secretion; nervous system development; neuromuscular synaptic transmission; protein kinase C-activating G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway; positive regulation of ion transport; positive regulation of cell population proliferation; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway; cell population proliferation; regulation of vascular associated smooth muscle contraction; signal transduction; G protein-coupled acetylcholine receptor signaling pathway; regulation of postsynaptic membrane potential; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; chemical synaptic transmission; G protein-coupled serotonin receptor signaling pathway; regulation of glial cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	1128
	12669
	ENSG00000168539
	ENSMUSG00000032773
	P11229
	P12657
	NM_000738
	NM_001112697; NM_007698
	NP_000729
	NP_001106167; NP_031724
	Wikidata
View/Edit Human	View/Edit Mouse

The muscarinic acetylcholine receptor M₁, also known as the cholinergic receptor, muscarinic 1, is a muscarinic receptor that in humans is encoded by the CHRM1 gene.^[5] It is localized to 11q13.^[5]

This receptor is found mediating slow EPSP at the ganglion in the postganglionic nerve,^[6] is common in exocrine glands and in the CNS.^[7]^[8]

It is predominantly found bound to G proteins of class G_q^[9]^[10] that use upregulation of phospholipase C and, therefore, inositol trisphosphate and intracellular calcium as a signalling pathway. A receptor so bound would not be susceptible to CTX or PTX. However, G_i (causing a downstream decrease in cAMP) and G_s (causing an increase in cAMP) have also been shown to be involved in interactions in certain tissues, and so would be susceptible to PTX and CTX respectively.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168539 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032773 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CHRM1 cholinergic receptor, muscarinic 1".
^ Messer WS (20 January 2000). "Acetylcholine". University of Toledo. Archived from the original on 14 October 2007. Retrieved 27 October 2007.
^ Johnson G (2002). PDQ Pharmacology (2nd ed.). Hamilton, Ontario: BC Decker Inc. pp. 311 pages. ISBN 1-55009-109-3.
^ Richelson E (1995). "Cholinergic Transduction". In Bloom FE, Kupfer DJ (eds.). Psychopharmacology: the fourth generation of progress: an official publication of the American College of Neuropsychopharmacology (Fourth ed.). New York: Lippincott Williams & Wilkins. ISBN 978-0781701662. Retrieved 27 October 2007.
^ Qin K, Dong C, Wu G, Lambert NA (August 2011). "Inactive-state preassembly of G(q)-coupled receptors and G(q) heterotrimers". Nature Chemical Biology. 7 (10): 740–747. doi:10.1038/nchembio.642. PMC 3177959. PMID 21873996.
^ Burford NT, Nahorski SR (May 1996). "Muscarinic m1 receptor-stimulated adenylate cyclase activity in Chinese hamster ovary cells is mediated by Gs alpha and is not a consequence of phosphoinositidase C activation". The Biochemical Journal. 315 (Pt 3): 883–888. doi:10.1042/bj3150883. PMC 1217289. PMID 8645172.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168539 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032773 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CHRM1 cholinergic receptor, muscarinic 1".

[Messer_2000-6] Messer WS (20 January 2000). "Acetylcholine". University of Toledo. Archived from the original on 14 October 2007. Retrieved 27 October 2007.

[isbn1-55009-109-3-7] Johnson G (2002). PDQ Pharmacology (2nd ed.). Hamilton, Ontario: BC Decker Inc. pp. 311 pages. ISBN 1-55009-109-3.

[Richelson_2000-8] Richelson E (1995). "Cholinergic Transduction". In Bloom FE, Kupfer DJ (eds.). Psychopharmacology: the fourth generation of progress: an official publication of the American College of Neuropsychopharmacology (Fourth ed.). New York: Lippincott Williams & Wilkins. ISBN 978-0781701662. Retrieved 27 October 2007.

[Kou_Qin-9] Qin K, Dong C, Wu G, Lambert NA (August 2011). "Inactive-state preassembly of G(q)-coupled receptors and G(q) heterotrimers". Nature Chemical Biology. 7 (10): 740–747. doi:10.1038/nchembio.642. PMC 3177959. PMID 21873996.

[pmid8645172-10] Burford NT, Nahorski SR (May 1996). "Muscarinic m1 receptor-stimulated adenylate cyclase activity in Chinese hamster ovary cells is mediated by Gs alpha and is not a consequence of phosphoinositidase C activation". The Biochemical Journal. 315 (Pt 3): 883–888. doi:10.1042/bj3150883. PMC 1217289. PMID 8645172.

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