NT5E

NT5E
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4H2B, 4H1Y, 4H2F, 4H2I, 4H1S, 4H2G
Identifiers
Aliases	NT5E, CALJA, CD73, E5NT, NT, NT5, NTE, eN, eNT, 5'-nucleotidase ecto
External IDs	OMIM: 129190; MGI: 99782; HomoloGene: 1895; GeneCards: NT5E; OMA:NT5E - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	85,495,791 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	88,254,145 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; Achilles tendon; ; jejunal mucosa; ; synovial joint; ; cartilage tissue; ; smooth muscle tissue; ; canal of the cervix; ; tendon of biceps brachii; ; germinal epithelium; ; tibia;
	Top expressed in
	epithelium of stomach; ; lumbar spinal ganglion; ; left colon; ; right kidney; ; seminal vesicula; ; granulocyte; ; neural layer of retina; ; retinal pigment epithelium; ; proximal tubule; ; skin of external ear;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; nucleotide binding; hydrolase activity, acting on ester bonds; hydrolase activity; 5'-nucleotidase activity;
Cellular component	anchored component of membrane; extracellular exosome; membrane; plasma membrane; cytosol; cell surface; nucleoplasm;
Biological process	pyrimidine nucleoside catabolic process; negative regulation of inflammatory response; purine nucleotide catabolic process; AMP catabolic process; adenosine biosynthetic process; dephosphorylation; DNA metabolic process; leukocyte cell-cell adhesion; nucleotide catabolic process; NAD metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	4907
	23959
	ENSG00000135318
	ENSMUSG00000032420
	P21589
	Q61503
	NM_002526; NM_001204813
	NM_011851
	NP_001191742; NP_002517
	NP_035981
	Wikidata
View/Edit Human	View/Edit Mouse

5′-nucleotidase (5′-NT), also known as ecto-5′-nucleotidase or CD73 (cluster of differentiation 73), is an enzyme that in humans is encoded by the NT5E gene.^[5] CD73 commonly serves to convert AMP to adenosine.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135318 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032420 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cite error: The named reference pmid2129526 was invoked but never defined (see the help page).
^ Allard B, Cousineau I, Spring K, et al. (2019-01-01), "Chapter Fifteen - Measurement of CD73 enzymatic activity using luminescence-based and colorimetric assays", in Galluzzi L, Rudqvist NP (eds.), Tumor Immunology and Immunotherapy – Molecular Methods, Methods in Enzymology, vol. 629, Academic Press, pp. 269–289, doi:10.1016/bs.mie.2019.10.007, ISBN 978-0-12-818671-8, PMID 31727245, S2CID 208035622, retrieved 2020-11-28

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135318 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032420 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2129526-5] Cite error: The named reference pmid2129526 was invoked but never defined (see the help page).

[6] Allard B, Cousineau I, Spring K, et al. (2019-01-01), "Chapter Fifteen - Measurement of CD73 enzymatic activity using luminescence-based and colorimetric assays", in Galluzzi L, Rudqvist NP (eds.), Tumor Immunology and Immunotherapy – Molecular Methods, Methods in Enzymology, vol. 629, Academic Press, pp. 269–289, doi:10.1016/bs.mie.2019.10.007, ISBN 978-0-12-818671-8, PMID 31727245, S2CID 208035622, retrieved 2020-11-28

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