Nadolol

Nadolol
Clinical data
Trade names	Corgard, others
AHFS/Drugs.com	Monograph
MedlinePlus	a682666
License data	US DailyMed: Nadolol;
Routes of; administration	By mouth
Drug class	Beta blocker
ATC code	C07AA12 (WHO) ;
Legal status
Legal status	UK: POM (Prescription only); US: WARNINGRx-only;
Pharmacokinetic data
Protein binding	30%
Metabolism	Not metabolised
Elimination half-life	14-24 hours
Excretion	Renal and fecal (unchanged)
Identifiers
	IUPAC name * rel-(2R,3S)-5-{[(2R)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-1,2,3,4-tetrahydronaphthalene-2,3-diol (2R,3S)-5-{[(2R*)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-1,2,3,4-tetrahydronaphthalene-2,3-diol; ;
CAS Number	42200-33-9 ;
PubChem CID	39147;
IUPHAR/BPS	554;
DrugBank	DB01203 ;
ChemSpider	35815 ;
UNII	FEN504330V;
KEGG	D00432 ;
ChEMBL	ChEMBL649 ;
CompTox Dashboard (EPA)	DTXSID3023342 ;
ECHA InfoCard	100.050.625
Chemical and physical data
Formula	C17H27NO4
Molar mass	309.406 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES OC(CNC(C)(C)C)COc1cccc2c1C[C@H](O)[C@H](O)C2;
	InChI InChI=1S/C17H27NO4/c1-17(2,3)18-9-12(19)10-22-16-6-4-5-11-7-14(20)15(21)8-13(11)16/h4-6,12,14-15,18-21H,7-10H2,1-3H3/t12?,14-,15+/m1/s1 ; Key:VWPOSFSPZNDTMJ-UCWKZMIHSA-N ;
	(verify)

Nadolol, sold under the brand name Corgard among others, is a medication used to treat high blood pressure, heart pain, atrial fibrillation, and some inherited arrhythmic syndromes.^[2] It has also been used to prevent migraine headaches and complications of cirrhosis.^[3]^[4] It is taken orally.^[3]

Common side effects include dizziness, feeling tired, a slow heart rate, and Raynaud syndrome.^[2] Serious side effects may include heart failure and bronchospasm.^[2] Its use in pregnancy and breastfeeding is of unclear safety.^[5] It is a non-selective beta blocker and works by blocking β1-adrenergic receptors in the heart and β2-adrenergic receptors in blood vessels.^[2]

Nadolol was patented in 1970 and came into medical use in 1978.^[6] It is available as a generic medication.^[2] In 2020, it was the 340th most commonly prescribed medication in the United States, with more than 700 thousand prescriptions.^[7]

^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
^ ^a ^b ^c ^d ^e "Nadolol Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
^ ^a ^b British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 148. ISBN 9780857113382.
^ Giannelli V, Lattanzi B, Thalheimer U, Merli M (2014). "Beta-blockers in liver cirrhosis". Annals of Gastroenterology. 27 (1): 20–26. PMC 3959530. PMID 24714633.
^ "Nadolol Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 460. ISBN 9783527607495.
^ "Nadolol - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.

[FDA-AllBoxedWarnings-1] "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.

[AHFS2019-2] "Nadolol Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.

[BNF76-3] British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 148. ISBN 9780857113382.

[Gia2014-4] Giannelli V, Lattanzi B, Thalheimer U, Merli M (2014). "Beta-blockers in liver cirrhosis". Annals of Gastroenterology. 27 (1): 20–26. PMC 3959530. PMID 24714633.

[Preg2019-5] "Nadolol Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.

[6] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 460. ISBN 9783527607495.

[7] "Nadolol - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.

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