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Nebivolol

Nebivolol
Clinical data
Trade namesNebilet, Bystolic, others
Other namesNarbivolol, Nebivolol, Nebivololum[1]
AHFS/Drugs.comMonograph
MedlinePlusa608029
License data
Pregnancy
category
  • AU: C
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding98%
MetabolismLiver (CYP2D6-mediated)
Elimination half-life12-19 hours[2][3][4]
ExcretionKidney and fecal
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC22H25F2NO4
Molar mass405.442 g·mol−1
3D model (JSmol)
  • Fc4cc1c(OC(CC1)C(O)CNCC(O)C3Oc2ccc(F)cc2CC3)cc4
  • InChI=1S/C22H25F2NO4/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2 checkY
  • Key:KOHIRBRYDXPAMZ-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)
Ebivol (Nebivolol) tablets

Nebivolol is a beta blocker used to treat high blood pressure and heart failure.[5] As with other β-blockers, it is generally a less preferred treatment for high blood pressure.[6] It may be used by itself or with other blood pressure medication.[6] It is taken by mouth.[6]

Common side effects include dizziness, feeling tired, nausea, and headaches.[6] Serious side effects may include heart failure and bronchospasm.[6] Its use in pregnancy and breastfeeding is not recommended.[5][7] It works by blocking β1-adrenergic receptors in the heart and dilating blood vessels.[6][8]

Nebivolol was patented in 1983 and came into medical use in 1997.[9] It is available as a generic medication in the United Kingdom.[5] In 2021, it was the 244th most commonly prescribed medication in the United States, with more than 1 million prescriptions.[10][11]

  1. ^ "Nebivolol". go.drugbank.com. Retrieved 17 August 2022.
  2. ^ "Drugs@FDA: FDA-Approved Drugs Nebivolol - ALLERGAN" (PDF). accessdata.fda.gov. Retrieved 17 August 2022.
  3. ^ Giles TD, Cockcroft JR, Pitt B, Jakate A, Wright HM (September 2017). "Rationale for nebivolol/valsartan combination for hypertension: review of preclinical and clinical data". Journal of Hypertension. 35 (9): 1758–1767. doi:10.1097/HJH.0000000000001412. PMC 5548499. PMID 28509722.
  4. ^ "DrugBank Nebivolol". go.drugbank.com. Retrieved 17 August 2022.
  5. ^ a b c British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 154. ISBN 9780857113382.
  6. ^ a b c d e f "Nebivolol Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
  7. ^ "Nebivolol Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.
  8. ^ de Boer RA, Voors AA, van Veldhuisen DJ (July 2007). "Nebivolol: third-generation beta-blockade". Expert Opinion on Pharmacotherapy. 8 (10): 1539–1550. doi:10.1517/14656566.8.10.1539. PMID 17661735. S2CID 24186687.
  9. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 462. ISBN 9783527607495.
  10. ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
  11. ^ "Nebivolol - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.

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