Nepafenac

Nepafenac
Clinical data
Trade names	Nevanac, Ilevro, Amnac, others
AHFS/Drugs.com	Monograph
MedlinePlus	a606007
License data	EU EMA: by INN; US DailyMed: Nepafenac;
Pregnancy; category	AU: C; ;
Routes of; administration	Topical eye drops
ATC code	S01BC10 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); US: ℞-only; In general: ℞ (Prescription only);
Identifiers
	IUPAC name 2-amino-3-benzoylbenzeneacetamide;
CAS Number	78281-72-8 ;
PubChem CID	151075;
IUPHAR/BPS	7564;
DrugBank	DB06802 ;
ChemSpider	133160 ;
UNII	0J9L7J6V8C;
KEGG	D05143 ;
ChEBI	CHEBI:75922 ;
ChEMBL	ChEMBL1021 ;
CompTox Dashboard (EPA)	DTXSID0048638 ;
ECHA InfoCard	100.207.414
Chemical and physical data
Formula	C15H14N2O2
Molar mass	254.289 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(c1cccc(c1N)CC(=O)N)c2ccccc2;
	InChI InChI=1S/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18) ; Key:QEFAQIPZVLVERP-UHFFFAOYSA-N ;
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Nepafenac, sold under the brand name Nevanac among others, is a nonsteroidal anti-inflammatory drug (NSAID), usually sold as a prescription eye drop 0.1% solution (Nevanac) or 0.3% solution (Ilevro). It is used to treat pain and inflammation associated with cataract surgery.^[3] Nepafenac is a prodrug of amfenac, an inhibitor of COX-1 and COX-2 activity.^[4]^[5]