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Neuromelanin

5,6-Dihydroxyindole, the monomer out of which neuromelanin polymers are formed

Neuromelanin (NM) is a dark pigment found in the brain which is structurally related to melanin. It is a polymer of 5,6-dihydroxyindole monomers.[1] Neuromelanin is found in large quantities in catecholaminergic cells of the substantia nigra pars compacta and locus coeruleus, giving a dark color to the structures mostly found in Black or Brown pigmented skin.[2]

  1. ^ Charkoudian LK, Franz KJ (2006). "Fe(III)-coordination properties of neuromelanin components: 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid". Inorganic Chemistry. 45 (9): 3657–64. doi:10.1021/ic060014r. PMID 16634598.
  2. ^ Fedorow, H; Tribl, F; Halliday, G; Gerlach, M; Riederer, P; Double, K. L. (2005). "Neuromelanin in human dopamine neurons: Comparison with peripheral melanins and relevance to Parkinson's disease". Progress in Neurobiology. 75 (2): 109–24. doi:10.1016/j.pneurobio.2005.02.001. PMID 15784302. S2CID 503902.

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