Nuclear bodies

Nuclear bodies (also known as nuclear domains, or nuclear dots) are membraneless structures found in the cell nuclei of eukaryotic cells.^[1] Nuclear bodies include Cajal bodies, the nucleolus, and promyelocytic leukemia protein (PML) nuclear bodies (also called PML oncogenic dots).^[2] Nuclear bodies also include ND10s. ND stands for nuclear domain, and 10 refers to the number of dots seen.^[3]

Nuclear bodies were first seen as prominent interchromatin structures in the nuclei of malignant or hyperstimulated animal cells^[4]^[5] identified using anti-sp100 autoantibodies from primary biliary cirrhosis and subsequently the promyelocytic leukemia (PML) factor, but appear also to be elevated in many autoimmune and cancerous diseases.^[6] Nuclear dots are metabolically stable and resistant to nuclease digestion and salt extraction.^[7]

A nuclear body subtype is a clastosome suggested to be a site of protein degradation.^[8]

^ Weber SC (June 2017). "Sequence-encoded material properties dictate the structure and function of nuclear bodies". Current Opinion in Cell Biology. 46: 62–71. doi:10.1016/j.ceb.2017.03.003. PMID 28343140.
^ Zimber A, Nguyen QD, Gespach C (October 2004). "Nuclear bodies and compartments: functional roles and cellular signalling in health and disease". Cellular Signalling. 16 (10): 1085–104. doi:10.1016/j.cellsig.2004.03.020. PMID 15240004.
^ Rivera-Molina YA, Martínez FP, Tang Q (August 2013). "Nuclear domain 10 of the viral aspect". World Journal of Virology. 2 (3): 110–22. doi:10.5501/wjv.v2.i3.110. PMC 3832855. PMID 24255882.
^ Brasch K, Ochs RL (October 1992). "Nuclear bodies (NBs): a newly "rediscovered" organelle". Experimental Cell Research. 202 (2): 211–23. doi:10.1016/0014-4827(92)90068-J. PMID 1397076.
^ Sternsdorf T, Grötzinger T, Jensen K, Will H (December 1997). "Nuclear dots: actors on many stages". Immunobiology. 198 (1–3): 307–31. doi:10.1016/s0171-2985(97)80051-4. PMID 9442402.
^ Pawlotsky JM, Andre C, Metreau JM, Beaugrand M, Zafrani ES, Dhumeaux D (July 1992). "Multiple nuclear dots antinuclear antibodies are not specific for primary biliary cirrhosis". Hepatology. 16 (1): 127–31. doi:10.1002/hep.1840160121. PMID 1319948. S2CID 22729443.
^ Ascoli CA, Maul GG (March 1991). "Identification of a novel nuclear domain". The Journal of Cell Biology. 112 (5): 785–95. doi:10.1083/jcb.112.5.785. PMC 2288866. PMID 1999457.
^ Lafarga M, Berciano MT, Pena E, Mayo I, Castaño JG, Bohmann D, et al. (August 2002). "Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome". Molecular Biology of the Cell. 13 (8): 2771–82. doi:10.1091/mbc.e02-03-0122. PMC 117941. PMID 12181345.

[Weber-1] Weber SC (June 2017). "Sequence-encoded material properties dictate the structure and function of nuclear bodies". Current Opinion in Cell Biology. 46: 62–71. doi:10.1016/j.ceb.2017.03.003. PMID 28343140.

[Zimber-2] Zimber A, Nguyen QD, Gespach C (October 2004). "Nuclear bodies and compartments: functional roles and cellular signalling in health and disease". Cellular Signalling. 16 (10): 1085–104. doi:10.1016/j.cellsig.2004.03.020. PMID 15240004.

[Rivera-Molina-3] Rivera-Molina YA, Martínez FP, Tang Q (August 2013). "Nuclear domain 10 of the viral aspect". World Journal of Virology. 2 (3): 110–22. doi:10.5501/wjv.v2.i3.110. PMC 3832855. PMID 24255882.

[pmid1397076-4] Brasch K, Ochs RL (October 1992). "Nuclear bodies (NBs): a newly "rediscovered" organelle". Experimental Cell Research. 202 (2): 211–23. doi:10.1016/0014-4827(92)90068-J. PMID 1397076.

[pmid9442402-5] Sternsdorf T, Grötzinger T, Jensen K, Will H (December 1997). "Nuclear dots: actors on many stages". Immunobiology. 198 (1–3): 307–31. doi:10.1016/s0171-2985(97)80051-4. PMID 9442402.

[pmid1319948-6] Pawlotsky JM, Andre C, Metreau JM, Beaugrand M, Zafrani ES, Dhumeaux D (July 1992). "Multiple nuclear dots antinuclear antibodies are not specific for primary biliary cirrhosis". Hepatology. 16 (1): 127–31. doi:10.1002/hep.1840160121. PMID 1319948. S2CID 22729443.

[pmid1999457-7] Ascoli CA, Maul GG (March 1991). "Identification of a novel nuclear domain". The Journal of Cell Biology. 112 (5): 785–95. doi:10.1083/jcb.112.5.785. PMC 2288866. PMID 1999457.

[Lafarga-8] Lafarga M, Berciano MT, Pena E, Mayo I, Castaño JG, Bohmann D, et al. (August 2002). "Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome". Molecular Biology of the Cell. 13 (8): 2771–82. doi:10.1091/mbc.e02-03-0122. PMC 117941. PMID 12181345.

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