OPN1LW | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | OPN1LW, CBBM, CBP, COD5, RCP, ROP, opsin 1 (cone pigments), long-wave-sensitive, opsin 1, long wave sensitive | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 300822; MGI: 1097692; HomoloGene: 68064; GeneCards: OPN1LW; OMA:OPN1LW - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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OPN1LW is a gene on the X chromosome that encodes for long wave sensitive (LWS) opsin, or red cone photopigment.[5] It is responsible for perception of visible light in the yellow-green range on the visible spectrum (around 500-570nm).[6][7] The gene contains 6 exons with variability that induces shifts in the spectral range.[8] OPN1LW is subject to homologous recombination with OPN1MW, as the two have very similar sequences.[8] These recombinations can lead to various vision problems, such as red-green colourblindness and blue monochromacy.[9] The protein encoded is a G-protein coupled receptor with embedded 11-cis-retinal, whose light excitation causes a cis-trans conformational change that begins the process of chemical signalling to the brain.[10]
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