Olmesartan

Olmesartan
Clinical data
Trade names	Benicar
Other names	Olmesartan medoxomil
AHFS/Drugs.com	Monograph
MedlinePlus	a603006
License data	US DailyMed: Olmesartan;
Routes of; administration	Oral
ATC code	C09CA08 (WHO) ; C09DA08 (WHO) (with diuretics); C09DB02 (WHO) (with amlodipine);
Legal status
Legal status	US: ℞-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	26%
Metabolism	Liver (cannot be removed by hemodialysis)
Elimination half-life	13 hours
Excretion	Kidney 40%, bile duct 60%
Identifiers
	IUPAC name (5-methyl-2-oxo-2H-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-imidazole-5-carboxylate;
CAS Number	144689-63-4 ;
PubChem CID	130881;
IUPHAR/BPS	591;
DrugBank	DB00275 ;
ChemSpider	115748 ;
UNII	6M97XTV3HD;
KEGG	D01204 ;
ChEBI	CHEBI:31932 ;
ChEMBL	ChEMBL1200692 ;
CompTox Dashboard (EPA)	DTXSID2040571 ;
ECHA InfoCard	100.174.243
Chemical and physical data
Formula	C29H30N6O6
Molar mass	558.595 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCc1nc(c(n1Cc2ccc(cc2)c3ccccc3c4[nH]nnn4)C(=O)OCc5c(oc(=O)o5)C)C(C)(C)O;
	InChI InChI=1S/C29H30N6O6/c1-5-8-23-30-25(29(3,4)38)24(27(36)39-16-22-17(2)40-28(37)41-22)35(23)15-18-11-13-19(14-12-18)20-9-6-7-10-21(20)26-31-33-34-32-26/h6-7,9-14,38H,5,8,15-16H2,1-4H3,(H,31,32,33,34) ; Key:UQGKUQLKSCSZGY-UHFFFAOYSA-N ;
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Olmesartan, sold under the brand name Benicar among others, is a medication used to treat high blood pressure (hypertension).^[1]^[2] It is taken orally (swallowed by mouth).^[2] Versions are available as the combination olmesartan/hydrochlorothiazide and olmesartan/amlodipine.^[2]

Common side effects include dizziness, headaches, diarrhea, and back pain.^[2] Serious side effects may include kidney problems, low blood pressure, and angioedema.^[2] Use in pregnancy may harm the fetus and use when breastfeeding is not recommended.^[3] It is an angiotensin II receptor antagonist and works by blocking the effects of angiotensin II.^[2]

It was patented in 1991 and came into medical use in 2002.^[4] It is available as a generic medication.^[5] In 2021, it was the 126th most commonly prescribed medication in the United States, with more than 4 million prescriptions.^[6]^[7]

^ ^a ^b "Benicar- olmesartan medoxomil tablet, film coated". DailyMed. 7 September 2022. Retrieved 14 April 2023.
^ ^a ^b ^c ^d ^e ^f "Olmesartan Medoxomil Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
^ "Olmesartan Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 471. ISBN 9783527607495.
^ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 177. ISBN 9780857113382.
^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^ "Olmesartan - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.

[Benicar_FDA_label-1] "Benicar- olmesartan medoxomil tablet, film coated". DailyMed. 7 September 2022. Retrieved 14 April 2023.

[AHFS2019-2] ^ ^a ^b ^c ^d ^e ^f "Olmesartan Medoxomil Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.

[Preg2019-3] "Olmesartan Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.

[Fis2006-4] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 471. ISBN 9783527607495.

[BNF76-5] British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 177. ISBN 9780857113382.

[6] "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.

[7] "Olmesartan - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.

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