Osteosarcoma

Osteosarcoma
Osteosarcoma
	Intermediate-magnification micrograph of an osteosarcoma (center and right of image) adjacent to non-malignant bone (left-bottom of image): The top-right of the image has poorly differentiated tumor. Osteoid with a high density of malignant cells is seen between the non-malignant bone and poorly differentiated tumor (H&E stain).
Specialty	Oncology

An osteosarcoma (OS) or osteogenic sarcoma (OGS) (or simply bone cancer) is a cancerous tumor in a bone. Specifically, it is an aggressive malignant neoplasm that arises from primitive transformed cells of mesenchymal origin (and thus a sarcoma) and that exhibits osteoblastic differentiation and produces malignant osteoid.^[1]

Osteosarcoma is the most common histological form of primary bone sarcoma.^[2] It is most prevalent in teenagers and young adults.^[3]

^ Luetke A, Meyers PA, Lewis A, Juergens H (2014). "Osteosarcoma treatment—where do we stand? A state of the art review". Cancer Treat Rev. 40 (4): 523–532. doi:10.1016/j.ctrv.2013.11.006. PMID 24345772.
^ Ottaviani G, Jaffe N (2009). "The Epidemiology of Osteosarcoma". Pediatric and Adolescent Osteosarcoma. Cancer Treatment and Research. Vol. 152. New York: Springer. pp. 3–13. doi:10.1007/978-1-4419-0284-9_1. ISBN 978-1-4419-0283-2. PMID 20213383.
^ "Osteosarcoma". US National Library of Medicine. PubMed Health. 2013.

[1] Luetke A, Meyers PA, Lewis A, Juergens H (2014). "Osteosarcoma treatment—where do we stand? A state of the art review". Cancer Treat Rev. 40 (4): 523–532. doi:10.1016/j.ctrv.2013.11.006. PMID 24345772.

[OttavianiJaffe-2] Ottaviani G, Jaffe N (2009). "The Epidemiology of Osteosarcoma". Pediatric and Adolescent Osteosarcoma. Cancer Treatment and Research. Vol. 152. New York: Springer. pp. 3–13. doi:10.1007/978-1-4419-0284-9_1. ISBN 978-1-4419-0283-2. PMID 20213383.

[3] "Osteosarcoma". US National Library of Medicine. PubMed Health. 2013.

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